Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 10/20 | 0.37 |
| ▸ | DRD2 | P14416 | 5/20 | 0.37 |
| ▸ | HTR2A | P28223 | 5/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.37 |
| ▸ | HTR1D | P28221 | 3/20 | 0.36 |
| ▸ | HTR1B | P28222 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6585292 | 0.88 | HTR1A (0.42) | HTR1ADRD2HTR2ASLC6A4HTR1D | |
| SCHEMBL6584265 | 0.85 | HTR1A (0.40) | HTR1ADRD2HTR2ASLC6A4HTR1D | |
| SCHEMBL6585830 | 0.85 | HTR1A (0.42) | HTR1ADRD2HTR2ASLC6A4HTR1D | |
| SCHEMBL6584859 | 0.84 | HTR1A (0.41) | HTR1ADRD2HTR2ASLC6A4MEN1 | |
| SCHEMBL6584452 | 0.83 | MEN1 (0.46) | HTR1ADRD2HTR1DHTR1BMEN1 | |
| SCHEMBL8309662 | 0.83 | HTR1A (0.40) | HTR1ADRD2HTR2ASLC6A4CYP2D6 | |
| SCHEMBL6583201 | 0.83 | DRD2 (0.41) | HTR1ADRD2HTR2ASLC6A4HTR1D | |
| SCHEMBL6585925 | 0.83 | GRM2 (0.45) | DRD2MAPTDRD3 | |
| SCHEMBL6581635 | 0.82 | HTR1A (0.40) | HTR1ADRD2HTR2ASLC6A4MEN1 | |
| SCHEMBL6585787 | 0.81 | MEN1 (0.43) | HTR1ADRD2HTR1DHTR1BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0957100-B1 | DIAMINE DERIVATIVES AND PHARMACEUTICAL CONTAINING THE SAME | KOWA CO (JP) | 2004-10-27 | — | — | EP | disclosed |
| EP-0957100-A1 | DIAMINE DERIVATIVES AND PHARMACEUTICAL CONTAINING THE SAME | Kowa Co., Ltd. (JP) | 1999-11-17 | — | — | EP | disclosed |