Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB1 | P11230 | 14/20 | 0.67 |
| ▸ | CHRNB2 | P17787 | 14/20 | 0.67 |
| ▸ | CHRNB4 | P30926 | 14/20 | 0.67 |
| ▸ | CHRNA3 | P32297 | 14/20 | 0.67 |
| ▸ | CHRNB3 | Q05901 | 14/20 | 0.67 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.48 |
| ▸ | FEN1 | P39748 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6589354 | 1.00 | CHRNB1 (0.67) | CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3 | |
| SCHEMBL6583208 | 0.95 | CHRNB1 (0.61) | CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3 | |
| SCHEMBL8240624 | 0.87 | ALOX5AP (0.51) | CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3 | |
| SCHEMBL8247133 | 0.87 | ALOX5AP (0.51) | CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3 | |
| SCHEMBL7672437 | 0.86 | CHRNB2 (0.63) | CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3 | |
| SCHEMBL3934735 | 0.86 | CHRNB2 (0.50) | CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3 | |
| SCHEMBL3356565 | 0.85 | CHRNB2 (0.49) | CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3 | |
| SCHEMBL6587032 | 0.85 | CHRNB4 (0.49) | CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3 | |
| SCHEMBL6586668 | 0.84 | CHRNB4 (0.66) | CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3 | |
| SCHEMBL6585505 | 0.84 | CHRNB2 (0.58) | CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934308-B1 | 3-PYRIDYLOXYMETHYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LAB (US) | 2004-08-11 | — | — | EP | disclosed |
| US-5629325-A | TREATMENT OF NERVOUS SYSTEM DISORDERS; NEURONAL NICOTINIC CHOLINERGIC COMPOUNDS | ABBOTT LABORATORIES (US) | 1997-05-13 | — | — | US | disclosed |