SCHEMBL7672437

SCHEMBL7672437

CC(C)(C)OC(=O)N1CCC[C@H]1COc1cncc(-c2cncnc2)c1

nearest known ligand 0.63

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 13/20 0.63
CHRNB4 P30926 13/20 0.63
CHRNA3 P32297 13/20 0.63
CHRNB1 P11230 12/20 0.63
CHRNB3 Q05901 12/20 0.63
CHRNA4 P43681 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6587447 0.94 CHRNB2 (0.56) CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3
SCHEMBL6586668 0.88 CHRNB4 (0.66) CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3
SCHEMBL6589354 0.86 CHRNB1 (0.67) CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3
SCHEMBL6584564 0.86 CHRNB1 (0.67) CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3
SCHEMBL6583880 0.85 CHRNB4 (0.51) CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3
SCHEMBL3357692 0.85 CHRNB2 (0.61) CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3
SCHEMBL14941814 0.85 CHRNB2 (0.50) CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3
SCHEMBL1241249 0.85 CHRNB2 (0.50) CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3
SCHEMBL6587123 0.85 CHRNB2 (0.61) CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3
SCHEMBL2495176 0.85 CHRNB2 (0.61) CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6437138-B1 5-BROMO-6-CHLORO-3-(2-(S)-AZETIDINYL OR PYRROLIDINYL-METHOXY) PYRIDINE INTERMEDIATES FOR THE 5-SUBSTITUTED COMPOUNDS WHICH ARE POTENT LIGANDS AT NEURONAL NICOTINIC CHOLINERGIC CHANNEL RECEPTORS, NEUROTRANSMITTER CONTROLLING AGENTS ABBOTT LABORATORIES 2002-08-20 US disclosed