SCHEMBL6584575

SCHEMBL6584575

COC(=O)C(Br)Cc1ccc(OCc2nc(-c3ccccc3)oc2C)c(F)c1

nearest known ligand 0.49

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 1/20 0.49
PPARG P37231 12/20 0.49
PPARA Q07869 8/20 0.49
KDR P35968 1/20 0.48
TP53 P04637 3/20 0.47
POLB P06746 1/20 0.46
MAPT P10636 1/20 0.46
PPARD Q03181 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6971980 0.89 FFAR1 (0.47) FFAR1PPARGPPARAKDRMAPT
SCHEMBL6385798 0.79 PPARG (0.66) PPARGPPARAPPARD
SCHEMBL6385792 0.79 PPARG (0.66) PPARGPPARAPPARD
SCHEMBL7157011 0.79 PPARG (0.72) PPARGPPARAPPARD
SCHEMBL6965085 0.78 KDR (0.53) FFAR1PPARGPPARAKDRMAPT
SCHEMBL9091541 0.78 PPARG (0.52) FFAR1PPARGPPARAKDRTP53
SCHEMBL6587031 0.77 PPARG (0.51) FFAR1PPARGPPARAKDRTP53
SCHEMBL6587033 0.77 PPARG (0.51) FFAR1PPARGPPARAKDRTP53
SCHEMBL8126485 0.76 PPARG (0.74) PPARGPPARA
SCHEMBL8337476 0.76 PPARG (0.49) FFAR1PPARGPPARAKDRTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0710659-B1 Oxazolidinedione derivatives, their production and use TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2004-01-28 EP disclosed
EP-0783496-B9 THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2003-09-03 EP disclosed
EP-0783496-B1 THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2003-03-26 EP disclosed
US-5965589-A AN ACTIVE MATERIAL HAVING HYPOGLYCEMIC ACTIVITY AND BLOOD LIPID LOWERING ACTIVITY, FOR USE AS AN ANTIDIABETIC AGENT TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1999-10-12 US disclosed
US-5932601-A USEFUL FOR LOWERING BLOOD SUGAR AND LIPID IN BLOOD TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1999-08-03 US disclosed
EP-0783496-A1 THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE Takeda Chemical Industries, Ltd. (JP) 1997-07-16 EP disclosed
EP-0710659-A1 Oxazolidinedione derivatives, their production and use TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-05-08 EP disclosed
WO-1996005186-A1 THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-02-22 WO disclosed