SCHEMBL6971980

SCHEMBL6971980

COC(=O)C(Br)Cc1ccc(OCc2nc(-c3ccccc3)oc2C)c(C(F)(F)F)c1

nearest known ligand 0.47

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 1/20 0.47
KDR P35968 1/20 0.46
PPARG P37231 15/20 0.46
PPARA Q07869 11/20 0.46
MAPT P10636 2/20 0.44
PPARD Q03181 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6584575 0.89 FFAR1 (0.49) FFAR1KDRPPARGPPARAMAPT
SCHEMBL8340638 0.82 KDR (0.50) FFAR1KDRPPARGPPARAMAPT
SCHEMBL8340510 0.78 MAPT (0.46) FFAR1KDRPPARGPPARAMAPT
SCHEMBL8340506 0.78 MAPT (0.46) FFAR1KDRPPARGPPARAMAPT
SCHEMBL7157011 0.77 PPARG (0.72) PPARGPPARAPPARD
SCHEMBL6965085 0.76 KDR (0.53) FFAR1KDRPPARGPPARAMAPT
SCHEMBL8126485 0.74 PPARG (0.74) PPARGPPARA
SCHEMBL6972047 0.74 KDR (0.49) FFAR1KDRPPARGPPARAMAPT
SCHEMBL8337350 0.74 KDR (0.45) FFAR1KDRPPARGPPARAMAPT
SCHEMBL8340640 0.74 KDR (0.49) FFAR1KDRPPARGPPARAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0783496-B9 THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2003-09-03 EP disclosed
EP-0783496-B1 THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2003-03-26 EP disclosed
US-5965589-A AN ACTIVE MATERIAL HAVING HYPOGLYCEMIC ACTIVITY AND BLOOD LIPID LOWERING ACTIVITY, FOR USE AS AN ANTIDIABETIC AGENT TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1999-10-12 US disclosed
EP-0783496-A1 THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE Takeda Chemical Industries, Ltd. (JP) 1997-07-16 EP disclosed
WO-1996005186-A1 THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-02-22 WO disclosed