Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 12/20 | 0.38 |
| ▸ | F2RL3 | Q96RI0 | 2/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6584804 | 0.90 | GPR119 (0.40) | GPR119F2RL3ALOX5APFEN1POLB | |
| Hydrochloric Acid SCHEMBL6583430 | 0.80 | CHRNB4 (0.47) | CHRNB1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL7409193 | 0.78 | CHRNB2 (0.54) | GPR119F2RL3CHRNB1CHRNB2CHRNB4 | |
| SCHEMBL7453857 | 0.78 | CHRNB2 (0.54) | GPR119F2RL3CHRNB1CHRNB2CHRNB4 | |
| SCHEMBL7415559 | 0.77 | POLB (0.50) | GPR119F2RL3ALOX5APFEN1POLB | |
| SCHEMBL7484779 | 0.77 | POLB (0.50) | GPR119F2RL3ALOX5APFEN1POLB | |
| Hydrochloric Acid SCHEMBL6581806 | 0.77 | CHRNB4 (0.56) | CHRNB1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL6587105 | 0.76 | F2RL3 (0.41) | GPR119F2RL3ALOX5APFEN1POLB | |
| SCHEMBL7415126 | 0.72 | CHRNB2 (0.61) | GPR119F2RL3ALOX5APFEN1CHRNB1 | |
| Hydrochloric Acid SCHEMBL6584849 | 0.72 | CHRNB2 (0.46) | CHRNB1CHRNB2CHRNB4CHRNA3CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934308-B1 | 3-PYRIDYLOXYMETHYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LAB (US) | 2004-08-11 | — | — | EP | disclosed |
| US-6437138-B1 | 5-BROMO-6-CHLORO-3-(2-(S)-AZETIDINYL OR PYRROLIDINYL-METHOXY) PYRIDINE INTERMEDIATES FOR THE 5-SUBSTITUTED COMPOUNDS WHICH ARE POTENT LIGANDS AT NEURONAL NICOTINIC CHOLINERGIC CHANNEL RECEPTORS, NEUROTRANSMITTER CONTROLLING AGENTS | ABBOTT LABORATORIES | 2002-08-20 | — | — | US | disclosed |
| US-6127386-A | STIMULANTS, NEUROTRANSMITTERS, CHOLINERGIC AGENTS | ABBOTT LABORATORIES (US) | 2000-10-03 | — | — | US | disclosed |
| US-5629325-A | TREATMENT OF NERVOUS SYSTEM DISORDERS; NEURONAL NICOTINIC CHOLINERGIC COMPOUNDS | ABBOTT LABORATORIES (US) | 1997-05-13 | — | — | US | disclosed |