Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.47 |
| ▸ | DPP4 | P27487 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.44 |
| ▸ | F2RL3 | Q96RI0 | 2/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7484779 | 1.00 | POLB (0.50) | POLBCHRNB2CHRNA4DPP4GPR119 | |
| SCHEMBL7453857 | 0.88 | CHRNB2 (0.54) | CHRNB2CHRNA4GPR119F2RL3CHRNB1 | |
| SCHEMBL7409193 | 0.88 | CHRNB2 (0.54) | CHRNB2CHRNA4GPR119F2RL3CHRNB1 | |
| SCHEMBL7415126 | 0.81 | CHRNB2 (0.61) | CHRNB2CHRNA4GPR119F2RL3ALOX5AP | |
| SCHEMBL7410033 | 0.81 | GPR119 (0.43) | CHRNB2CHRNA4GPR119ALOX5APFEN1 | |
| SCHEMBL27462042 | 0.81 | GPR119 (0.48) | POLBGPR119ALOX5APFEN1 | |
| SCHEMBL7412041 | 0.81 | ALOX5AP (0.50) | POLBCHRNB2CHRNA4F2RL3ALOX5AP | |
| SCHEMBL21845257 | 0.81 | ALOX5AP (0.50) | POLBCHRNB2CHRNA4F2RL3ALOX5AP | |
| SCHEMBL29960520 | 0.81 | ALOX5AP (0.50) | POLBCHRNB2CHRNA4F2RL3ALOX5AP | |
| SCHEMBL3361683 | 0.80 | UCHL1 (0.41) | POLBGPR119ALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1125064-C | 3-pyridyl enantiomers and their use as analgesics | ABBOTT LAB (US) | 2003-10-22 | — | — | CN | disclosed |
| EP-0950057-B1 | 3-PYRIDYL ENANTIOMERS AND THEIR USE AS ANALGESICS | ABBOTT LAB (US) | 2002-11-13 | — | — | EP | disclosed |
| US-6403575-B1 | ANTI-INFLAMMATORIES | ABBOTT LABORATORIES | 2002-06-11 | — | — | US | disclosed |
| EP-1047690-A1 | HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | Abbott Laboratories (US) | 2000-11-02 | — | — | EP | disclosed |
| US-6133253-A | NEURONAL CELL DEATH PREVENTORS AND ANTI-INFLAMMATORIES | ABBOTT LABORATORIES (US) | 2000-10-17 | — | — | US | disclosed |
| CN-1245496-A | 3-pyridyl enantiomers and their use as analgesics | ABBOTT LAB (US) | 2000-02-23 | — | — | CN | disclosed |
| WO-1999032480-A1 | HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LABORATORIES (US) | 1999-07-01 | — | — | WO | disclosed |