Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.70 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.70 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.70 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.70 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | SMPD1 | P17405 | 5/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7153812 | 0.92 | PDE4A (0.81) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL6583889 | 0.91 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL6942928 | 0.89 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL9712873 | 0.85 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL8890661 | 0.84 | PDE4A (0.73) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL7332426 | 0.83 | KMT2A (0.60) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL7369768 | 0.82 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL28957152 | 0.82 | SMPD1 (0.73) | PDE4BKMT2ASMPD1MAOB | |
| SCHEMBL9236564 | 0.82 | SMPD1 (0.73) | NPC1RAB9AKMT2ASMPD1HDAC1 | |
| SCHEMBL7376634 | 0.81 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0928789-B1 | 6-PHENYLTETRAHYDRO-1,3-OXAZIN-2-ONE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME | NIKKEN CHEMICALS CO LTD (JP) | 2004-09-29 | — | — | EP | disclosed |
| US-6251897-B1 | TREATING DERMATITIS, ASTHMA | NIKKEN CHEMICALS CO., LTD (JP) | 2001-06-26 | — | — | US | disclosed |
| EP-0928789-A1 | 6-PHENYLTETRAHYDRO-1,3-OXAZIN-2-ONE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME | Nikken Chemicals Company, Limited (JP) | 1999-07-14 | — | — | EP | disclosed |