Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 11/20 | 1.00 |
| ▸ | PDE4B | Q07343 | 11/20 | 1.00 |
| ▸ | PDE4C | Q08493 | 11/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 11/20 | 1.00 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.53 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.53 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.51 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.50 |
| ▸ | RXRA | P19793 | 1/20 | 0.50 |
| ▸ | PTAFR | P25105 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7376634 | 0.92 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPTAFR | |
| SCHEMBL7153812 | 0.90 | PDE4A (0.81) | PDE4APDE4BPDE4CPDE4DPLA2G4B | |
| SCHEMBL678960 | 0.86 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPTPN11 | |
| SCHEMBL8890661 | 0.84 | PDE4A (0.73) | PDE4APDE4BPDE4CPDE4DMRGPRX4 | |
| SCHEMBL8683735 | 0.83 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4DPTPN11 | |
| SCHEMBL6584958 | 0.82 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6942928 | 0.81 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7151164 | 0.81 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9712873 | 0.80 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL17844309 | 0.79 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DMRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0672031-A1 | CATECHOL DIETHERS AS SELECTIVE PDE IV? INHIBITORS | PFIZER INC. (US) | 1995-09-20 | — | — | EP | disclosed |
| WO-1994012461-A1 | CATECHOL DIETHERS AS SELECTIVE PDEIV INHIBITORS | PFIZER INC. (US) | 1994-06-09 | — | — | WO | disclosed |