Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 5/20 | 0.76 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.76 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.76 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.76 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | CA4 | P22748 | 1/20 | 0.51 |
| ▸ | CA6 | P23280 | 1/20 | 0.51 |
| ▸ | CA7 | P43166 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7153812 | 0.87 | PDE4A (0.81) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL7376634 | 0.86 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL6584958 | 0.85 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL17844309 | 0.84 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL30622576 | 0.84 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL4278415 | 0.84 | NPC1 (0.73) | MAPK1KMT2ANPC1RAB9AHPGD | |
| SCHEMBL6942928 | 0.84 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL8068426 | 0.82 | MAPK1 (0.68) | PDE4APDE4BPDE4CPDE4DMAPK1 | |
| SCHEMBL23630666 | 0.81 | MAPK1 (0.71) | PDE4BMAPK1PRSS1TSHR | |
| SCHEMBL598033 | 0.81 | MAPK1 (0.71) | PDE4BMAPK1PRSS1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5140046-A | Slow reacting substance of anaphylaxis antagonists | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1992-08-18 | — | — | US | disclosed |
| US-5116853-A | SRS-Antagonist, Antiallergens | MASE TOSHIYASU (JP) | 1992-05-26 | — | — | US | disclosed |
| US-4994479-A | Antagonists of SRS-A(slow reacting substance of anaphylaxis); antiallergens, antiischemic agents | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1991-02-19 | — | — | US | disclosed |
| EP-0218728-A1 | PHENYLENE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1987-04-22 | — | — | EP | disclosed |
| WO-1986005779-A1 | PHENYLENE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1986-10-09 | — | — | WO | disclosed |