Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 0.69 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.69 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.69 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.69 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | SMPD1 | P17405 | 5/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8890208 | 0.91 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL7153812 | 0.91 | PDE4A (0.81) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL6584958 | 0.89 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL9712873 | 0.84 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL9308281 | 0.83 | SMPD1 (0.71) | PDE4APDE4BPDE4CPDE4DSMPD1 | |
| SCHEMBL8890661 | 0.83 | PDE4A (0.73) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL184987 | 0.83 | SMPD1 (0.71) | NPC1RAB9AKMT2ASMPD1HDAC1 | |
| SCHEMBL7369768 | 0.81 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7376634 | 0.81 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL7332411 | 0.80 | SMPD1 (0.63) | PDE4APDE4BPDE4CPDE4DSMPD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0869945-B1 | CATECHOL DIETHERS DERIVATIVES USEFUL AS PHARMACEUTICAL AGENTS | PFIZER (US) | 2003-04-16 | — | — | EP | disclosed |
| US-6028086-A | SELECTIVE INHIBITORS OF PHOSPHODIESTERASE (PDE) TYPE IV OR PRODUCTION OF TUMOR NECROSIS FACTOR (TNF) AND AS SUCH ARE USEFUL TREATMENT OF ASTHMA, ARTHRITIS, BRONCHITIS, CHRONIC OBSTRUCTIVE AIRWAYS DISEASE, PSORIASIS, ALLERGIC RHINITIS | P PFIZER INC (US) | 2000-02-22 | — | — | US | disclosed |
| EP-0869945-A1 | CATECHOL DIETHERS DERIVATIVES USEFUL AS PHARMACEUTICAL AGENTS | PFIZER INC. (US) | 1998-10-14 | — | — | EP | disclosed |
| WO-1996040636-A1 | CATECHOL DIETHERS DERIVATIVES USEFUL AS PHARMACEUTICAL AGENTS | PFIZER INC. (US) | 1996-12-19 | — | — | WO | disclosed |