Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.69 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.63 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.63 |
| ▸ | RAF1 | P04049 | 2/20 | 0.57 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8891758 | 0.95 | APP (0.62) | APPMTNR1AMTNR1BRAF1MAP2K1 | |
| SCHEMBL8888747 | 0.92 | APP (0.57) | APPMTNR1AMTNR1BRAF1MAP2K1 | |
| SCHEMBL5881099 | 0.92 | APP (0.73) | APPMTNR1AMTNR1BNPC1RAB9A | |
| SCHEMBL6583603 | 0.87 | APP (0.66) | APPMTNR1AMTNR1BNPC1RAB9A | |
| SCHEMBL9724394 | 0.84 | APP (0.62) | APPMTNR1AMTNR1BNPC1RAB9A | |
| SCHEMBL10826159 | 0.84 | MTNR1A (0.53) | APPMTNR1AMTNR1BRAF1MAP2K1 | |
| SCHEMBL5208237 | 0.84 | APP (0.69) | APPMTNR1AMTNR1BNPC1RAB9A | |
| SCHEMBL6583392 | 0.84 | APP (0.62) | APPMTNR1AMTNR1BRAF1MAP2K1 | |
| SCHEMBL8890494 | 0.83 | APP (0.61) | APPMTNR1AMTNR1BSMN1; SMN2FFAR4 | |
| SCHEMBL11733932 | 0.83 | LMNA (0.55) | APPSMN1; SMN2CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0710659-B1 | Oxazolidinedione derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2004-01-28 | — | — | EP | disclosed |
| US-5932601-A | USEFUL FOR LOWERING BLOOD SUGAR AND LIPID IN BLOOD | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-08-03 | — | — | US | disclosed |
| WO-1997000249-A1 | HETEROCYCLIC COMPOUNDS, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-01-03 | — | — | WO | disclosed |
| EP-0710659-A1 | Oxazolidinedione derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-05-08 | — | — | EP | disclosed |