SCHEMBL6585899

SCHEMBL6585899

COC(=O)C(C1CCNCC1)N1CCC(N)CC1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A3 Q01959 7/20 0.43
SLC6A2 P23975 5/20 0.43
SLC6A4 P31645 5/20 0.43
PADI1 Q9ULC6 1/20 0.37
PADI4 Q9UM07 1/20 0.37
CCR2 P41597 1/20 0.34
ITGB3 P05106 1/20 0.32
ITGA2B P08514 1/20 0.32
F2R P25116 1/20 0.32
TP53 P04637 1/20 0.31
CPN1 P15169 1/20 0.31
CPB2 Q96IY4 1/20 0.31
DPP4 P27487 1/20 0.31
MMP1 P03956 1/20 0.30
MMP2 P08253 1/20 0.30
MMP3 P08254 1/20 0.30
MMP7 P09237 1/20 0.30
MMP9 P14780 1/20 0.30
MMP8 P22894 1/20 0.30
MMP13 P45452 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6584546 0.84 SLC6A2 (0.35) SLC6A3SLC6A2SLC6A4CPN1CPB2
SCHEMBL6586012 0.82 SMYD3 (0.32) SLC6A3SLC6A2SLC6A4CPN1CPB2
SCHEMBL6585188 0.81 CPN1 (0.34) SLC6A3SLC6A2SLC6A4CCR2CPN1
SCHEMBL6586743 0.81 CPN1 (0.32) SLC6A3SLC6A2SLC6A4CPN1CPB2
SCHEMBL6587799 0.80 SLC6A2 (0.31) SLC6A3SLC6A2SLC6A4CPN1CPB2
SCHEMBL7839828 0.77 OPRD1 (0.38) SLC6A3SLC6A2SLC6A4CPN1CPB2
SCHEMBL6584313 0.77 DPP4 (0.37) CPN1CPB2DPP4
SCHEMBL6586715 0.75 CA2 (0.38) DPP4
SCHEMBL6584321 0.73
SCHEMBL2550030 0.73 TP53 (0.46) SLC6A3PADI1PADI4TP53MMP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1076055-B1 1- (1-SUBSTITUTED-4-PIPERIDINYL)METHYL]-4-PIPERIDINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES OF THESE COMPOUNDS DAINIPPON PHARMACEUTICAL CO (JP) 2004-11-24 EP disclosed
US-6294555-B1 SEROTONIN HT3 RECEPTOR ANTAGONIST FOR GASTROINTESTINAL DISORDERS DAINIPPON PHARMACEUTICAL CO., LTD. (JP) 2001-09-25 US disclosed
EP-1076055-A1 1- (1-SUBSTITUTED-4-PIPERIDINYL)METHYL]-4-PIPERIDINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES OF THESE COMPOUNDS Dainippon Pharmaceutical Co., Ltd. (JP) 2001-02-14 EP disclosed