Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6585979 | 0.89 | KDM4E (0.41) | KDM4ERECQLTNKSPARP1TNKS2 | |
| SCHEMBL6585873 | 0.89 | PARP14 (0.34) | TNKSTNKS2PARP14 | |
| SCHEMBL6583698 | 0.78 | PARP14 (0.35) | TNKSTNKS2PARP14 | |
| SCHEMBL6585952 | 0.77 | TRPM8 (0.34) | — | |
| SCHEMBL13255227 | 0.76 | DHFR (0.38) | KDM4ERECQL | |
| SCHEMBL988539 | 0.75 | TYMS (0.39) | KDM4ERECQL | |
| SCHEMBL988538 | 0.75 | TYMS (0.39) | KDM4ERECQL | |
| SCHEMBL988271 | 0.74 | DHFR (0.37) | KDM4ERECQL | |
| SCHEMBL988272 | 0.74 | DHFR (0.37) | KDM4ERECQL | |
| SCHEMBL6580579 | 0.74 | SMN1; SMN2 (0.41) | KDM4ETNKSTNKS2PARP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1155012-B1 | ANTI-CANCER DIHYDROQUINAZOLINE DERIVATIVES | CANCER REC TECH LTD (GB) | 2004-04-14 | — | — | EP | disclosed |
| US-6699861-B1 | ANTI-CANCER | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2004-03-02 | — | — | US | disclosed |
| EP-1155012-A1 | ANTI-CANCER DIHYDROQUINAZOLINE DERIVATIVES | Cancer Research Ventures Limited (GB) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000050417-A1 | ANTI-CANCER DIHYDROQUINAZOLINE DERIVATIVES | CANCER RESEARCH VENTURES LIMITED (GB) | 2000-08-31 | — | — | WO | disclosed |