Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 4/20 | 1.00 |
| ▸ | CHRNA4 | P43681 | 4/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.59 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14941047 | 1.00 | CHRNB2 (1.00) | CHRNB2CHRNA4KDM4ECYP1A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL6584096 | 0.99 | CHRNB2 (0.97) | CHRNB2CHRNA4KDM4ECYP1A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL6585349 | 0.99 | CHRNB2 (0.97) | CHRNB2CHRNA4KDM4ECYP1A2CYP2D6 | |
| SCHEMBL6585946 | 0.91 | CHRNB2 (0.83) | CHRNB2CHRNA4CHRNA3 | |
| SCHEMBL6584663 | 0.91 | CHRNB2 (0.83) | CHRNB2CHRNA4CHRNA3 | |
| Hydrochloric Acid SCHEMBL6588481 | 0.90 | CHRNB2 (0.81) | CHRNB2CHRNA4CHRNA3 | |
| Hydrochloric Acid SCHEMBL6583887 | 0.90 | CHRNB2 (0.81) | CHRNB2CHRNA4CHRNA3 | |
| SCHEMBL6583461 | 0.86 | CHRNB2 (0.75) | CHRNB2CHRNA4KDM4ECYP1A2CYP2D6 | |
| SCHEMBL6584512 | 0.86 | CHRNB2 (0.75) | CHRNB2CHRNA4KDM4ECYP1A2CYP2D6 | |
| SCHEMBL2186420 | 0.85 | CHRNB2 (0.73) | CHRNB2CHRNA4CHRNA3CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934308-B1 | 3-PYRIDYLOXYMETHYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LAB (US) | 2004-08-11 | — | — | EP | claimed |
| US-6127386-A | STIMULANTS, NEUROTRANSMITTERS, CHOLINERGIC AGENTS | ABBOTT LABORATORIES (US) | 2000-10-03 | — | — | US | claimed |
| EP-0934308-A1 | 3-PYRIDYLOXYMETHYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | Abbott Laboratories (US) | 1999-08-11 | — | — | EP | claimed |
| WO-1997046554-A1 | 3-PYRIDYLOXYMETHYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LABORATORIES (US) | 1997-12-11 | — | — | WO | claimed |
| EP-2776423-B1 | PHENYL-SUBSTITUTED NICOTINIC LIGANDS, AND METHODS OF USE THEREOF | UNIV GEORGETOWN (US) | 2020-05-06 | — | — | EP | disclosed |
| EP-2776423-B1 | PHENYL-SUBSTITUTED NICOTINIC LIGANDS, AND METHODS OF USE THEREOF | UNIV GEORGETOWN (US) | 2020-05-06 | — | — | EP | disclosed |
| US-9994548-B2 | Phenyl-substituted nicotinic ligands, and methods of use thereof | GEORGETOWN UNIVERSITY (US) | 2018-06-12 | — | — | US | disclosed |
| US-9994548-B2 | Phenyl-substituted nicotinic ligands, and methods of use thereof | GEORGETOWN UNIVERSITY (US) | 2018-06-12 | — | — | US | disclosed |
| US-20170107197-A1 | PHENYL-SUBSTITUTED NICOTINIC LIGANDS, AND METHODS OF USE THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-04-20 | — | — | US | disclosed |
| US-20170107197-A1 | PHENYL-SUBSTITUTED NICOTINIC LIGANDS, AND METHODS OF USE THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-04-20 | — | — | US | disclosed |
| US-9346784-B2 | Phenyl-substituted nicotinic ligands, and methods of use thereof | GEORGETOWN UNIVERSITY (US) | 2016-05-24 | — | — | US | disclosed |
| US-9346784-B2 | Phenyl-substituted nicotinic ligands, and methods of use thereof | GEORGETOWN UNIVERSITY (US) | 2016-05-24 | — | — | US | disclosed |
| EP-2776423-A1 | PHENYL-SUBSTITUTED NICOTINIC LIGANDS, AND METHODS OF USE THEREOF | Georgetown University (US) | 2014-09-17 | — | — | EP | disclosed |
| WO-2013071067-A1 | PHENYL-SUBSTITUTED NICOTINIC LIGANDS, AND METHODS OF USE THEREOF | GEORGETOWN UNIVERSITY (US) | 2013-05-16 | — | — | WO | disclosed |
| EP-0934308-B1 | 3-PYRIDYLOXYMETHYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LAB (US) | 2004-08-11 | — | — | EP | disclosed |
| US-6437138-B1 | 5-BROMO-6-CHLORO-3-(2-(S)-AZETIDINYL OR PYRROLIDINYL-METHOXY) PYRIDINE INTERMEDIATES FOR THE 5-SUBSTITUTED COMPOUNDS WHICH ARE POTENT LIGANDS AT NEURONAL NICOTINIC CHOLINERGIC CHANNEL RECEPTORS, NEUROTRANSMITTER CONTROLLING AGENTS | ABBOTT LABORATORIES | 2002-08-20 | — | — | US | disclosed |
| US-6127386-A | STIMULANTS, NEUROTRANSMITTERS, CHOLINERGIC AGENTS | ABBOTT LABORATORIES (US) | 2000-10-03 | — | — | US | disclosed |
| EP-0934308-A1 | 3-PYRIDYLOXYMETHYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | Abbott Laboratories (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1997046554-A1 | 3-PYRIDYLOXYMETHYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LABORATORIES (US) | 1997-12-11 | — | — | WO | disclosed |
| US-5629325-A | TREATMENT OF NERVOUS SYSTEM DISORDERS; NEURONAL NICOTINIC CHOLINERGIC COMPOUNDS | ABBOTT LABORATORIES (US) | 1997-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170107197-A1 | PHENYL-SUBSTITUTED NICOTINIC LIGANDS, AND METHODS OF USE THEREOF | PSEN1, PNMT, OPRL1 | CHRNB2 56/4885CHRNA4 12/4885KDM4E 3852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.