Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 4/20 | 0.51 |
| ▸ | PIM3 | Q86V86 | 4/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.51 |
| ▸ | GSK3A | P49840 | 3/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.51 |
| ▸ | STK17A | Q9UEE5 | 3/20 | 0.51 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.51 |
| ▸ | PHKG2 | P15735 | 2/20 | 0.51 |
| ▸ | CLK2 | P49760 | 2/20 | 0.51 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | CSF1R | P07333 | 1/20 | 0.51 |
| ▸ | MARK3 | P27448 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
| ▸ | ITK | Q08881 | 1/20 | 0.51 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6586074 | 0.95 | PIM1 (0.46) | PIM1PIM3AURKBCLK4GSK3A | |
| SCHEMBL6585966 | 0.91 | PKN2 (0.48) | PIM1PIM3AURKBCLK4GSK3A | |
| SCHEMBL6810110 | 0.88 | PIM1 (0.66) | PIM1PIM3AURKBCLK4GSK3A | |
| SCHEMBL6585579 | 0.88 | PKN2 (0.43) | PIM1PIM3AURKBCLK4GSK3A | |
| SCHEMBL7764199 | 0.85 | PIM1 (0.55) | PIM1PIM3AURKBCLK4GSK3A | |
| Hydrochloric Acid SCHEMBL6587717 | 0.84 | PIM1 (0.54) | PIM1PIM3AURKBCLK4GSK3A | |
| SCHEMBL6809854 | 0.84 | PIM1 (0.60) | PIM1PIM3AURKBCLK4GSK3A | |
| SCHEMBL7763607 | 0.83 | AURKB (0.58) | PIM1PIM3AURKBCLK4GSK3A | |
| SCHEMBL6587758 | 0.82 | PARP1 (0.57) | PIM1PIM3AURKBCLK4GSK3A | |
| SCHEMBL6583719 | 0.81 | PARP1 (0.43) | PIM1PIM3AURKBCLK4GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177178-B1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | ABBOTT GMBH & CO KG (DE) | 2004-12-29 | — | — | EP | disclosed |