Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 5/20 | 1.00 |
| ▸ | MMP2 | P08253 | 4/20 | 0.47 |
| ▸ | MMP13 | P45452 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | MMP12 | P39900 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 2/20 | 0.45 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.45 |
| ▸ | MMP14 | P50281 | 1/20 | 0.45 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.45 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4654716 | 0.89 | MMP3 (0.85) | MMP3MMP2MMP13ALDH1A1MMP9 | |
| SCHEMBL6585216 | 0.87 | MMP3 (1.00) | MMP3MMP2MMP13ALDH1A1MMP9 | |
| SCHEMBL6590110 | 0.86 | MMP3 (0.76) | MMP3SMN1; SMN2ALDH1A1LMNARECQL | |
| SCHEMBL6588226 | 0.75 | MMP3 (0.60) | MMP3MMP2MMP13ALDH1A1HDAC6 | |
| SCHEMBL6585983 | 0.74 | MMP3 (0.62) | MMP3MMP2MMP13SMN1; SMN2ALDH1A1 | |
| SCHEMBL6584929 | 0.74 | MMP3 (0.72) | MMP3MMP2MMP13ALDH1A1LMNA | |
| SCHEMBL6587821 | 0.73 | MMP3 (0.73) | MMP3MMP2MMP9MMP1MMP14 | |
| SCHEMBL7474955 | 0.71 | ALDH1A1 (0.66) | MMP3SMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL945091 | 0.70 | MMP3 (0.54) | MMP3SMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL12041706 | 0.70 | S1PR1 (0.69) | MMP3ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036062-B1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE (MMP) INHIBITORS | PFIZER LTD (GB) | 2004-01-02 | — | — | EP | disclosed |
| US-6495568-B1 | TREATMENT OF TISSUE ULCERATION, WOUND REPAIR AND SKIN DISEASES | WARNER-LAMBERT COMPANY | 2002-12-17 | — | — | US | disclosed |
| EP-1036062-A1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE (MMP) INHIBITORS | Pfizer Limited (GB) | 2000-09-20 | — | — | EP | disclosed |
| WO-1999029667-A1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE (MMP) INHIBITORS | PFIZER LIMITED (GB) | 1999-06-17 | — | — | WO | disclosed |