Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 5/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | CHUK | O15111 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.44 |
| ▸ | MMP2 | P08253 | 2/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | USP5 | P45974 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6588226 | 0.92 | MMP3 (0.60) | MMP3ALDH1A1MAPTHPGDNPSR1 | |
| SCHEMBL6590110 | 0.88 | MMP3 (0.76) | MMP3ALDH1A1MAPTHPGDNPSR1 | |
| SCHEMBL6585216 | 0.84 | MMP3 (1.00) | MMP3ALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL6434485 | 0.78 | MMP3 (0.47) | MMP3ALDH1A1MAPTHPGDNPSR1 | |
| SCHEMBL6586759 | 0.78 | MAPT (0.60) | ALDH1A1MAPTHPGDNPSR1HSD17B10 | |
| SCHEMBL6588468 | 0.77 | MMP3 (0.58) | MMP3ALDH1A1MMP2USP5 | |
| SCHEMBL6590060 | 0.77 | MMP3 (0.73) | MMP3ALDH1A1KDM4EHSD11B1MMP2 | |
| SCHEMBL6586996 | 0.76 | MMP3 (0.74) | MMP3ALDH1A1MAPTLMNATSHR | |
| SCHEMBL4654716 | 0.76 | MMP3 (0.85) | MMP3ALDH1A1KDM4EHSD11B1MMP2 | |
| SCHEMBL6590876 | 0.75 | MMP3 (0.69) | MMP3MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036062-B1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE (MMP) INHIBITORS | PFIZER LTD (GB) | 2004-01-02 | — | — | EP | disclosed |
| US-6495568-B1 | TREATMENT OF TISSUE ULCERATION, WOUND REPAIR AND SKIN DISEASES | WARNER-LAMBERT COMPANY | 2002-12-17 | — | — | US | disclosed |