Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 11/20 | 0.47 |
| ▸ | MMP3 | P08254 | 11/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6584658 | 0.81 | MMP2 (0.51) | MMP2MMP3KDM4ENPC1RAB9A | |
| SCHEMBL6586244 | 0.80 | MMP2 (0.49) | MMP2MMP3 | |
| SCHEMBL6587603 | 0.78 | MMP2 (0.48) | MMP2MMP3CCNT1CDK9 | |
| SCHEMBL6582915 | 0.78 | MMP2 (0.72) | MMP2MMP3CCNT1CDK9 | |
| SCHEMBL6437646 | 0.78 | MMP2 (0.48) | MMP2MMP3CCNT1CDK9LMNA | |
| SCHEMBL6588048 | 0.76 | MMP2 (0.57) | MMP2MMP3CCNT1CDK9KDM4E | |
| SCHEMBL6590027 | 0.76 | MMP2 (0.61) | MMP2MMP3CCNT1CDK9 | |
| SCHEMBL6590755 | 0.76 | MMP2 (0.52) | MMP2MMP3CCNT1CDK9KDM4E | |
| SCHEMBL6439725 | 0.74 | MMP2 (0.62) | MMP2MMP3CCNT1CDK9 | |
| SCHEMBL6587154 | 0.73 | MMP2 (0.52) | MMP2MMP3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036062-B1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE (MMP) INHIBITORS | PFIZER LTD (GB) | 2004-01-02 | — | — | EP | disclosed |
| US-6495568-B1 | TREATMENT OF TISSUE ULCERATION, WOUND REPAIR AND SKIN DISEASES | WARNER-LAMBERT COMPANY | 2002-12-17 | — | — | US | disclosed |