Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 20/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 20/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 20/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 20/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7655262 | 0.85 | ALDH1A1 (0.33) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6588385 | 0.75 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6586401 | 0.73 | PDE4A (0.39) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7653066 | 0.70 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6274069 | 0.68 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL7651294 | 0.67 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL7655513 | 0.66 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL7657365 | 0.66 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL7658146 | 0.65 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL7650498 | 0.65 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1097142-B1 | PHTHALAZINE DERIVATIVES PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON SPA (IT) | 2004-10-13 | — | — | EP | disclosed |
| US-6329370-B1 | CARDIOVASCULAR DISORDERS AND TUMOR NECROSIS FACTOR (HEREINAFTER TNF.SUB..ALPHA.), A CYTOKINE WITH PRO-INFLAMMATORY ACTIVITY | ZAMBON GROUP S.P.A. (IT) | 2001-12-11 | — | — | US | disclosed |