Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 14/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 14/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 14/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 14/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7655256 | 0.86 | MAPT (0.35) | KDM4EKMT2AMTNR1BMTNR1APDCD1LG2 | |
| SCHEMBL6586405 | 0.73 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6586855 | 0.69 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3945116 | 0.65 | SIGMAR1 (0.36) | PDCD1LG2CD274HCRTR1HCRTR2 | |
| SCHEMBL4518720 | 0.64 | MTNR1B (0.56) | KDM4EKMT2AMTNR1BMTNR1A | |
| SCHEMBL6682094 | 0.63 | ATM (0.57) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5503363 | 0.63 | MMP13 (0.36) | KDM4EKMT2APDCD1LG2CD274 | |
| SCHEMBL15617129 | 0.62 | SIGMAR1 (0.54) | — | |
| SCHEMBL16460307 | 0.62 | SIGMAR1 (0.54) | — | |
| SCHEMBL5500218 | 0.61 | MMP13 (0.38) | KDM4EKMT2APDCD1LG2CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1097142-B1 | PHTHALAZINE DERIVATIVES PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON SPA (IT) | 2004-10-13 | — | — | EP | disclosed |
| US-6329370-B1 | CARDIOVASCULAR DISORDERS AND TUMOR NECROSIS FACTOR (HEREINAFTER TNF.SUB..ALPHA.), A CYTOKINE WITH PRO-INFLAMMATORY ACTIVITY | ZAMBON GROUP S.P.A. (IT) | 2001-12-11 | — | — | US | disclosed |