Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LIPE | Q05469 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 4/20 | 0.32 |
| ▸ | TNF | P01375 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 5/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6586405 | 0.85 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7655256 | 0.73 | MAPT (0.35) | ALDH1A1MAPTL3MBTL1KDM4EHPGD | |
| SCHEMBL17664012 | 0.62 | SMN1; SMN2 (0.50) | ALDH1A1MAPTPOLBSMN1; SMN2CYP2C9 | |
| SCHEMBL6586401 | 0.62 | PDE4A (0.39) | KDM4EPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6588385 | 0.60 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4518720 | 0.59 | MTNR1B (0.56) | KDM4E | |
| SCHEMBL9701845 | 0.59 | ABCC9 (0.43) | MAPTKDM4ESMN1; SMN2CYP1A2CYP2C9 | |
| SCHEMBL9587862 | 0.59 | ABCC9 (0.43) | MAPTKDM4ESMN1; SMN2CYP1A2CYP2C9 | |
| SCHEMBL3950819 | 0.56 | OPRM1 (0.38) | ALDH1A1CD274 | |
| SCHEMBL7816033 | 0.55 | TP53 (0.48) | ALDH1A1MAPTHPGDPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492360-B1 | Phthalazine derivatives phosphodiesterase 4 inhibitors | ZAMBON GROUP S.P.A. (IT) | 2002-12-10 | — | — | US | disclosed |