Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 9/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.59 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.52 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.52 |
| ▸ | QDPR | P09417 | 3/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP3 | P08254 | 1/20 | 0.47 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3961889 | 0.82 | SIGMAR1 (0.65) | HTR2CSIGMAR1QDPRMMP2MMP3 | |
| SCHEMBL3382904 | 0.80 | HTR2C (0.58) | HTR2CSIGMAR1PDE3BPDE3AQDPR | |
| SCHEMBL27007790 | 0.80 | PDE3B (0.53) | HTR2CSIGMAR1PDE3BPDE3AQDPR | |
| SCHEMBL6584948 | 0.79 | SIGMAR1 (0.65) | HTR2CSIGMAR1QDPRHTR6HTR7 | |
| SCHEMBL186263 | 0.79 | HTR2C (0.57) | HTR2CSIGMAR1PDE3BPDE3AQDPR | |
| Hydrochloric Acid SCHEMBL1961556 | 0.78 | HTR2C (0.58) | HTR2CSIGMAR1PDE3BPDE3AQDPR | |
| SCHEMBL5541715 | 0.77 | HTR2C (0.58) | HTR2CSIGMAR1PDE3BPDE3AQDPR | |
| SCHEMBL3899585 | 0.77 | SIGMAR1 (0.92) | HTR2CSIGMAR1QDPRHTR6HTR7 | |
| SCHEMBL415545 | 0.77 | SIGMAR1 (1.00) | HTR2CSIGMAR1QDPRHTR6HTR7 | |
| Trifluoroacetic Acid SCHEMBL30746013 | 0.76 | PDE3B (0.50) | HTR2CSIGMAR1PDE3BPDE3AQDPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036062-B1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE (MMP) INHIBITORS | PFIZER LTD (GB) | 2004-01-02 | — | — | EP | disclosed |
| US-6495568-B1 | TREATMENT OF TISSUE ULCERATION, WOUND REPAIR AND SKIN DISEASES | WARNER-LAMBERT COMPANY | 2002-12-17 | — | — | US | disclosed |
| EP-1036062-A1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE (MMP) INHIBITORS | Pfizer Limited (GB) | 2000-09-20 | — | — | EP | disclosed |
| WO-1999029667-A1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE (MMP) INHIBITORS | PFIZER LIMITED (GB) | 1999-06-17 | — | — | WO | disclosed |