Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | CTSK | P43235 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27081047 | 0.91 | CTSK (0.48) | EPHX2KCNA3CTSKCYP2C9HSD11B1 | |
| SCHEMBL2483799 | 0.83 | DRD2 (0.61) | DRD2KCNA3DRD3CTSKCYP2C9 | |
| SCHEMBL6588958 | 0.82 | DRD2 (0.51) | DRD2KCNA3DRD3CTSKCYP2C9 | |
| SCHEMBL6584897 | 0.82 | DRD2 (0.51) | DRD2KCNA3CTSKCYP2C9HSD11B1 | |
| SCHEMBL6586590 | 0.81 | DRD2 (0.49) | DRD2KCNA3DRD3CTSKCYP2C9 | |
| SCHEMBL6586545 | 0.81 | ALDH1A1 (0.51) | DRD2KCNA3CTSKCYP2C9HSD11B1 | |
| SCHEMBL1604214 | 0.80 | DRD2 (0.55) | DRD2KCNA3CTSK | |
| SCHEMBL8187882 | 0.80 | DRD2 (0.55) | DRD2KCNA3CTSK | |
| SCHEMBL29260224 | 0.78 | EPHX2 (0.55) | EPHX2KCNA3CTSKCYP2C9HSD11B1 | |
| SCHEMBL24321071 | 0.78 | DRD2 (0.43) | DRD2DRD3HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1076055-B1 | 1- (1-SUBSTITUTED-4-PIPERIDINYL)METHYL]-4-PIPERIDINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES OF THESE COMPOUNDS | DAINIPPON PHARMACEUTICAL CO (JP) | 2004-11-24 | — | — | EP | disclosed |
| US-6294555-B1 | SEROTONIN HT3 RECEPTOR ANTAGONIST FOR GASTROINTESTINAL DISORDERS | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 2001-09-25 | — | — | US | disclosed |
| EP-1076055-A1 | 1- (1-SUBSTITUTED-4-PIPERIDINYL)METHYL]-4-PIPERIDINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES OF THESE COMPOUNDS | Dainippon Pharmaceutical Co., Ltd. (JP) | 2001-02-14 | — | — | EP | disclosed |