Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.36 |
| ▸ | LTB4R | Q15722 | 6/20 | 0.35 |
| ▸ | CYSLTR2 | Q9NS75 | 5/20 | 0.34 |
| ▸ | CYSLTR1 | Q9Y271 | 5/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9184832 | 0.75 | MEN1 (0.52) | MEN1MAPTKMT2ATLR8LTB4R | |
| SCHEMBL9186725 | 0.75 | MEN1 (0.52) | MEN1MAPTKMT2ATLR8LTB4R | |
| SCHEMBL28276324 | 0.73 | TLR8 (0.60) | MEN1MAPTKMT2ATLR8CYSLTR2 | |
| SCHEMBL16114537 | 0.73 | TLR8 (0.60) | MEN1MAPTKMT2ATLR8CYSLTR2 | |
| SCHEMBL3529969 | 0.72 | CHRNB2 (0.50) | MAPTKMT2A | |
| SCHEMBL368050 | 0.72 | TLR8 (0.59) | MEN1MAPTKMT2ATLR8CYSLTR2 | |
| SCHEMBL9645267 | 0.71 | MEN1 (0.48) | MEN1MAPTKMT2ATLR8LTB4R | |
| SCHEMBL9645289 | 0.71 | MEN1 (0.48) | MEN1MAPTKMT2ATLR8LTB4R | |
| SCHEMBL3531115 | 0.71 | CA12 (0.50) | MAPT | |
| SCHEMBL6607586 | 0.70 | MEN1 (0.56) | MEN1MAPTKMT2ATLR8LTB4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397355-A1 | PYRIDYL CYANOGUANIDINE COMPOUNDS | Leo Pharma A/S (DK) | 2004-03-17 | — | — | EP | disclosed |
| WO-2002094813-A1 | NOVEL PYRIDYL CYANOGUANIDINE COMPOUNDS | LEO PHARMA A/S (DK) | 2002-11-28 | — | — | WO | disclosed |