Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 17/20 | 0.57 |
| ▸ | MMP3 | P08254 | 10/20 | 0.57 |
| ▸ | MMP9 | P14780 | 10/20 | 0.53 |
| ▸ | MMP13 | P45452 | 9/20 | 0.53 |
| ▸ | MMP1 | P03956 | 3/20 | 0.53 |
| ▸ | MMP14 | P50281 | 3/20 | 0.53 |
| ▸ | MMP8 | P22894 | 2/20 | 0.53 |
| ▸ | ADAM10 | O14672 | 2/20 | 0.51 |
| ▸ | MMP10 | P09238 | 1/20 | 0.47 |
| ▸ | MMP12 | P39900 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6584500 | 0.89 | MMP2 (0.53) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL6584009 | 0.89 | MMP2 (0.64) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL6585027 | 0.86 | MMP2 (0.51) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL6585833 | 0.85 | MMP2 (0.60) | MMP2MMP3MMP9MMP1MMP14 | |
| SCHEMBL6586040 | 0.80 | MMP2 (0.68) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL6584742 | 0.80 | MMP2 (0.68) | MMP2MMP3MMP9MMP1ADAM10 | |
| SCHEMBL6588157 | 0.78 | MMP2 (0.70) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL6583989 | 0.78 | MMP2 (0.60) | MMP2MMP3MMP14ALDH1A1PKM | |
| SCHEMBL6586997 | 0.77 | MMP2 (0.59) | MMP2MMP3MMP9MMP1ADAM10 | |
| SCHEMBL6586008 | 0.77 | MMP2 (0.58) | MMP2MMP3MMP9MMP13MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036062-B1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE (MMP) INHIBITORS | PFIZER LTD (GB) | 2004-01-02 | — | — | EP | disclosed |
| US-6495568-B1 | TREATMENT OF TISSUE ULCERATION, WOUND REPAIR AND SKIN DISEASES | WARNER-LAMBERT COMPANY | 2002-12-17 | — | — | US | disclosed |