Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 8/20 | 0.53 |
| ▸ | MMP3 | P08254 | 8/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 2/20 | 0.43 |
| ▸ | MMP9 | P14780 | 2/20 | 0.43 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MMP14 | P50281 | 2/20 | 0.42 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.42 |
| ▸ | USP5 | P45974 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6586758 | 0.89 | MMP2 (0.57) | MMP2MMP3ALDH1A1PKMMMP1 | |
| SCHEMBL6585027 | 0.88 | MMP2 (0.51) | MMP2MMP3ALDH1A1PKMKDM4E | |
| SCHEMBL6583989 | 0.88 | MMP2 (0.60) | MMP2MMP3ALDH1A1PKML3MBTL1 | |
| SCHEMBL6586045 | 0.83 | MMP2 (0.55) | MMP2MMP3ALDH1A1PKMKDM4E | |
| SCHEMBL6965353 | 0.83 | MMP2 (0.46) | MMP2MMP3ALDH1A1PKML3MBTL1 | |
| SCHEMBL6584555 | 0.80 | MMP2 (0.63) | MMP2MMP3KDM4EL3MBTL1MMP9 | |
| SCHEMBL6586997 | 0.79 | MMP2 (0.59) | MMP2MMP3PKMKDM4EL3MBTL1 | |
| SCHEMBL6584009 | 0.79 | MMP2 (0.64) | MMP2MMP3L3MBTL1MMP1MMP9 | |
| SCHEMBL6586078 | 0.78 | MMP2 (0.64) | MMP2MMP3ALDH1A1PKML3MBTL1 | |
| SCHEMBL6588431 | 0.78 | MMP2 (0.66) | MMP2MMP3L3MBTL1MMP1MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036062-B1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE (MMP) INHIBITORS | PFIZER LTD (GB) | 2004-01-02 | — | — | EP | disclosed |
| US-6495568-B1 | TREATMENT OF TISSUE ULCERATION, WOUND REPAIR AND SKIN DISEASES | WARNER-LAMBERT COMPANY | 2002-12-17 | — | — | US | disclosed |