Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 5/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6587560 | 0.85 | PARP1 (0.42) | PARP1RAB9ARXFP1MAPTSMN1; SMN2 | |
| SCHEMBL6810783 | 0.85 | PARP1 (0.56) | PARP1DHODH | |
| SCHEMBL7481617 | 0.81 | GAA (0.52) | RAB9AMAPTSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL6587520 | 0.78 | PARP1 (0.46) | PARP1MAPK1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL6587182 | 0.75 | MEN1 (0.52) | PARP1MAPTSMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL6590978 | 0.74 | PARP1 (0.42) | PARP1RAB9ANPC1 | |
| SCHEMBL6585205 | 0.74 | PARP1 (0.42) | PARP1RAB9AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL7471031 | 0.73 | PARP1 (0.45) | PARP1MAPTALDH1A1DHODH | |
| SCHEMBL6810792 | 0.73 | RCE1 (0.43) | PARP1MAPK1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL6591702 | 0.72 | PARP1 (0.44) | PARP1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177178-B1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | ABBOTT GMBH & CO KG (DE) | 2004-12-29 | — | — | EP | disclosed |