Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 9/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MGAM | O43451 | 1/20 | 0.38 |
| ▸ | SI | P14410 | 1/20 | 0.38 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6586777 | 0.85 | PARP1 (0.40) | PARP1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6804451 | 0.85 | PARP1 (0.60) | PARP1PTGS2PLA2G2AALOX15 | |
| SCHEMBL6585205 | 0.83 | PARP1 (0.42) | PARP1GAAMGAMSIMGAM2 | |
| SCHEMBL6590978 | 0.81 | PARP1 (0.42) | PARP1GAAMGAMSIMGAM2 | |
| SCHEMBL6591702 | 0.79 | PARP1 (0.44) | PARP1GAAMGAMSIMGAM2 | |
| SCHEMBL7764171 | 0.76 | PARP1 (0.47) | PARP1GAAMGAMSIMGAM2 | |
| SCHEMBL6587289 | 0.75 | PARP1 (0.49) | PARP1GAAMGAMSIMGAM2 | |
| SCHEMBL6591596 | 0.74 | PARP1 (0.48) | PARP1GAAMGAMSIMGAM2 | |
| SCHEMBL6589144 | 0.74 | PARP1 (0.42) | PARP1GAAMGAMSIMGAM2 | |
| SCHEMBL6804457 | 0.73 | PARP1 (0.42) | PARP1GAAMAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177178-B1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | ABBOTT GMBH & CO KG (DE) | 2004-12-29 | — | — | EP | disclosed |