Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 12/20 | 0.44 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | SI | P14410 | 1/20 | 0.36 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.36 |
| ▸ | PKN1 | Q16512 | 2/20 | 0.35 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7478464 | 0.92 | PARP1 (0.41) | PARP1NR3C2GAAMGAMSI | |
| SCHEMBL6807081 | 0.84 | PARP1 (0.64) | PARP1PKN1PKN2PLK4MAPK13 | |
| SCHEMBL6585205 | 0.81 | PARP1 (0.42) | PARP1GAAMGAMSIMGAM2 | |
| SCHEMBL6587560 | 0.79 | PARP1 (0.42) | PARP1GAAMGAMSIMGAM2 | |
| SCHEMBL6591596 | 0.79 | PARP1 (0.48) | PARP1GAAMGAMSIMGAM2 | |
| SCHEMBL6587289 | 0.78 | PARP1 (0.49) | PARP1GAAMGAMSIMGAM2 | |
| SCHEMBL6590978 | 0.75 | PARP1 (0.42) | PARP1GAAMGAMSIMGAM2 | |
| SCHEMBL6589391 | 0.75 | LMNA (0.46) | PARP1GAAMGAMSIMGAM2 | |
| SCHEMBL6591504 | 0.73 | PARP1 (0.49) | PARP1GAAMGAMSIMGAM2 | |
| SCHEMBL6807085 | 0.72 | NR3C2 (0.43) | PARP1NR3C2PKN1PKN2PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177178-B1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | ABBOTT GMBH & CO KG (DE) | 2004-12-29 | — | — | EP | disclosed |