Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | PARP1 | P09874 | 8/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | ATP4A | P20648 | 3/20 | 0.41 |
| ▸ | ATP4B | P51164 | 3/20 | 0.41 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6588249 | 0.84 | PARP1 (0.45) | MEN1KMT2AALDH1A1KDM4ELMNA | |
| SCHEMBL6585095 | 0.82 | DHODH (0.47) | PARP1HPSEDHODHPTGS2 | |
| SCHEMBL6806325 | 0.82 | PARP1 (0.62) | MEN1KMT2AALDH1A1HPGDHSD17B10 | |
| SCHEMBL7471031 | 0.79 | PARP1 (0.45) | MEN1KMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL6588173 | 0.78 | PARP1 (0.49) | MEN1KMT2AALDH1A1PARP1HPSE | |
| SCHEMBL6585540 | 0.77 | CBFB (0.47) | ALDH1A1HPGDHSD17B10PARP1HPSE | |
| SCHEMBL6585078 | 0.77 | PARP1 (0.44) | ALDH1A1HPGDHSD17B10PARP1HPSE | |
| SCHEMBL6592136 | 0.77 | PARP1 (0.43) | ALDH1A1HPGDHSD17B10PARP1HPSE | |
| SCHEMBL6586959 | 0.76 | KDM4E (0.56) | MEN1KMT2AALDH1A1HPGDHSD17B10 | |
| SCHEMBL7479706 | 0.75 | PARP1 (0.49) | PARP1HPSEALOX15PLA2G2APTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177178-B1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | ABBOTT GMBH & CO KG (DE) | 2004-12-29 | — | — | EP | disclosed |
| EP-1177178-A1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | BASF AKTIENGESELLSCHAFT (DE) | 2002-02-06 | — | — | EP | disclosed |
| WO-2001082877-A2 | USE OF PARP INHIBITORS IN COSMETIC PREPARATIONS | BASF AKTIENGESELLSCHAFT (DE) | 2001-11-08 | — | — | WO | disclosed |
| WO-2000068206-A1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | BASF AKTIENGESELLSCHAFT (DE) | 2000-11-16 | — | — | WO | disclosed |