Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 17/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 17/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 17/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 17/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6586401 | 0.69 | PDE4A (0.39) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6682094 | 0.67 | ATM (0.57) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6274069 | 0.63 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5307497 | 0.63 | EGFR (0.49) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL28062485 | 0.63 | CYP11B1 (0.57) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1437913 | 0.60 | NPC1 (0.43) | CYP19A1 | |
| SCHEMBL585761 | 0.60 | HTR2C (0.43) | CYP19A1HTR2A | |
| SCHEMBL6587900 | 0.59 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL28706083 | 0.59 | NSD2 (0.49) | — | |
| SCHEMBL19202358 | 0.59 | CHRNB2 (0.54) | HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1097142-B1 | PHTHALAZINE DERIVATIVES PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON SPA (IT) | 2004-10-13 | — | — | EP | disclosed |
| US-6492360-B1 | Phthalazine derivatives phosphodiesterase 4 inhibitors | ZAMBON GROUP S.P.A. (IT) | 2002-12-10 | — | — | US | disclosed |
| US-6329370-B1 | CARDIOVASCULAR DISORDERS AND TUMOR NECROSIS FACTOR (HEREINAFTER TNF.SUB..ALPHA.), A CYTOKINE WITH PRO-INFLAMMATORY ACTIVITY | ZAMBON GROUP S.P.A. (IT) | 2001-12-11 | — | — | US | disclosed |
| EP-1097142-A1 | PHTHALAZINE DERIVATIVES PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON GROUP S.p.A. (IT) | 2001-05-09 | — | — | EP | disclosed |
| WO-2000005218-A1 | PHTHALAZINE DERIVATIVES PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON GROUP S.P.A. (IT) | 2000-02-03 | — | — | WO | disclosed |