Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 12/20 | 0.58 |
| ▸ | MAOB | P27338 | 12/20 | 0.58 |
| ▸ | DRD2 | P14416 | 7/20 | 0.56 |
| ▸ | HTR1A | P08908 | 3/20 | 0.56 |
| ▸ | HTR2A | P28223 | 3/20 | 0.56 |
| ▸ | HTR7 | P34969 | 3/20 | 0.56 |
| ▸ | HTR2C | P28335 | 2/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.56 |
| ▸ | DRD3 | P35462 | 2/20 | 0.56 |
| ▸ | DRD4 | P21917 | 1/20 | 0.56 |
| ▸ | HTR6 | P50406 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6585295 | 0.99 | MAOA (0.59) | MAOAMAOBDRD2HTR1AHTR2A | |
| SCHEMBL6583194 | 0.97 | DRD2 (0.60) | MAOAMAOBDRD2HTR1AHTR2A | |
| SCHEMBL6585123 | 0.97 | MAOA (0.61) | MAOAMAOBDRD2HTR1AHTR2A | |
| SCHEMBL6588613 | 0.96 | MAOA (0.61) | MAOAMAOBDRD2HTR1AHTR2A | |
| SCHEMBL6583493 | 0.95 | DRD2 (0.54) | MAOAMAOBDRD2HTR1AHTR2A | |
| SCHEMBL6589109 | 0.95 | DRD2 (0.62) | MAOAMAOBDRD2HTR1AHTR2A | |
| SCHEMBL6584969 | 0.94 | MAOA (0.67) | MAOAMAOBDRD2 | |
| SCHEMBL6585490 | 0.93 | MAOA (0.68) | MAOAMAOBDRD2 | |
| SCHEMBL8308852 | 0.93 | DRD2 (0.54) | MAOAMAOBDRD2HTR1AHTR2A | |
| SCHEMBL6585754 | 0.92 | DRD2 (0.56) | MAOAMAOBDRD2HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0957100-B1 | DIAMINE DERIVATIVES AND PHARMACEUTICAL CONTAINING THE SAME | KOWA CO (JP) | 2004-10-27 | — | — | EP | disclosed |
| EP-0957100-A1 | DIAMINE DERIVATIVES AND PHARMACEUTICAL CONTAINING THE SAME | Kowa Co., Ltd. (JP) | 1999-11-17 | — | — | EP | disclosed |