Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SORD | Q00796 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4274947 | 0.78 | RXRA (0.40) | TSHR | |
| SCHEMBL6026053 | 0.78 | NPSR1 (0.38) | NPSR1KDM5AKDM5BMAPTKMT2A | |
| SCHEMBL16815402 | 0.77 | CCR1 (0.36) | NPC1KDM4EALOX12HTTRAB9A | |
| SCHEMBL2633102 | 0.77 | — | — | |
| SCHEMBL30997750 | 0.76 | TUBB4A (0.36) | KDM5AKDM5BTSHRLMNA | |
| SCHEMBL4765915 | 0.76 | TUBB4A (0.36) | KDM5AKDM5BTSHRLMNA | |
| SCHEMBL8496930 | 0.76 | LOX (0.39) | KDM5AKDM5BTSHR | |
| SCHEMBL1014696 | 0.76 | NOS1 (0.38) | NPC1KDM4ERAB9AKDM5AKDM5B | |
| SCHEMBL29442793 | 0.76 | LOX (0.39) | KDM5AKDM5BTSHR | |
| SCHEMBL25986828 | 0.74 | RXRA (0.34) | KDM5AKDM5BTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4605394-A1 | PYRIMIDINE SGC STIMULATORS | Tisento Therapeutics Inc. (US) | 2025-08-27 | — | — | EP | disclosed |
| WO-2025087763-A1 | PYRIDINE AND PYRIMIDINE DERIVATIVES AS HERBICIDES | SYNGENTA CROP PROTECTION AG (CH) | 2025-05-01 | — | — | WO | disclosed |
| WO-2024086179-A1 | PYRIMIDINE SGC STIMULATORS | TISENTO THERAPEUTICS, INC. (US) | 2024-04-25 | — | — | WO | disclosed |
| EP-1041068-B1 | Compounds for treating and preventing diabetic complications | PFIZER PROD INC (US) | 2004-04-14 | — | — | EP | disclosed |
| US-6294538-B1 | ANTIDIABETIC AGENTS AND DIABETIC NEUROPATHY, TREATMENT WITH OXIDOREDUCTASE ENZYMES | PFIZER INC. | 2001-09-25 | — | — | US | disclosed |
| EP-1041068-A1 | Compounds for treating and preventing diabetic complications | Pfizer Products Inc. (US) | 2000-10-04 | — | — | EP | disclosed |
| US-5215990-A | Screening for aldose reductase inhibitors | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-06-01 | — | — | US | disclosed |
| EP-0470616-A2 | Substituted pyrimidin derivatives, process for their preparation and their use as reagent | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-02-12 | — | — | EP | disclosed |
| EP-0002200-B1 | N,N-DIALKYL-O-PYRIMIDINYL-CARBAMIC ACID ESTERS, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS INSECTICIDES | BAYER AG (DE) | 1981-09-02 | — | — | EP | disclosed |
| US-4200637-A | Combating arthropods with N,N-dialkyl-O-(2-substituted-methyl-pyrimidin-4-yl)-carbamic acid esters | BAYER AKTIENGESELLSCHAFT (DE) | 1980-04-29 | — | — | US | disclosed |
| EP-0002200-A1 | N,N-dialkyl-O-pyrimidinyl-carbamic acid esters, process for their preparation, and their use as insecticides | BAYER AG (DE) | 1979-06-13 | — | — | EP | disclosed |