Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.51 |
| ▸ | BACE1 | P56817 | 2/20 | 0.51 |
| ▸ | BLM | P54132 | 2/20 | 0.51 |
| ▸ | GLA | P06280 | 2/20 | 0.51 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | CCR1 | P32246 | 2/20 | 0.41 |
| ▸ | CCR5 | P51681 | 2/20 | 0.41 |
| ▸ | CCR8 | P51685 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | METAP1 | P53582 | 1/20 | 0.41 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6587379 | 0.83 | BACE1 (0.47) | LMNABACE1BLMGLABACE2 | |
| SCHEMBL6591928 | 0.79 | BACE1 (0.61) | LMNABACE1BLMGLABACE2 | |
| SCHEMBL6588437 | 0.73 | BACE1 (0.50) | LMNABACE1BLMGLABACE2 | |
| SCHEMBL6589473 | 0.72 | BACE1 (0.53) | LMNABACE1BLMGLABACE2 | |
| SCHEMBL6589904 | 0.72 | BACE1 (0.53) | LMNABACE1BLMGLABACE2 | |
| SCHEMBL6591279 | 0.72 | BACE1 (0.53) | LMNABACE1BLMGLABACE2 | |
| SCHEMBL6829481 | 0.70 | KMT2A (0.50) | LMNABACE1BLMGLABACE2 | |
| SCHEMBL6600448 | 0.69 | BACE1 (0.49) | LMNABACE1BLMGLABACE2 | |
| SCHEMBL6593173 | 0.69 | KMT2A (0.49) | LMNABACE1BLMGLABACE2 | |
| SCHEMBL6593802 | 0.69 | BACE1 (0.49) | LMNABACE1BLMGLABACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066278-A4 | IMIDAZOLONE ANORECTIC AGENTS: III. HETEROARYL DERIVATIVES | BRISTOL MYERS SQUIBB CO (US) | 2004-09-01 | — | — | EP | disclosed |
| EP-1066278-A1 | IMIDAZOLONE ANORECTIC AGENTS: III. HETEROARYL DERIVATIVES | Bristol-Myers Squibb Company (US) | 2001-01-10 | — | — | EP | disclosed |
| WO-1999048887-A1 | IMIDAZOLONE ANORECTIC AGENTS: III. HETEROARYL DERIVATIVES | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-09-30 | — | — | WO | disclosed |