Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 5/20 | 0.47 |
| ▸ | BACE2 | Q9Y5Z0 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | CTSD | P07339 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6587050 | 0.83 | LMNA (0.51) | BACE1BACE2LMNAGLATHRB | |
| SCHEMBL6588437 | 0.79 | BACE1 (0.50) | BACE1BACE2LMNAGLATHRB | |
| SCHEMBL6584810 | 0.76 | BACE1 (0.54) | BACE1BACE2LMNAGLATHRB | |
| SCHEMBL6591928 | 0.76 | BACE1 (0.61) | BACE1BACE2LMNAGLATHRB | |
| SCHEMBL6591279 | 0.75 | BACE1 (0.53) | BACE1BACE2LMNAGLATHRB | |
| SCHEMBL4459149 | 0.72 | NISCH (0.41) | BACE1BACE2KMT2AMETAP2KDM4E | |
| SCHEMBL6589904 | 0.69 | BACE1 (0.53) | BACE1BACE2LMNAGLATHRB | |
| SCHEMBL6589473 | 0.69 | BACE1 (0.53) | BACE1BACE2LMNAGLATHRB | |
| SCHEMBL8173896 | 0.67 | KMT2A (0.50) | BACE1BACE2LMNAGLATHRB | |
| SCHEMBL6829481 | 0.67 | KMT2A (0.50) | BACE1BACE2LMNAGLATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066278-A4 | IMIDAZOLONE ANORECTIC AGENTS: III. HETEROARYL DERIVATIVES | BRISTOL MYERS SQUIBB CO (US) | 2004-09-01 | — | — | EP | disclosed |
| EP-1066278-A1 | IMIDAZOLONE ANORECTIC AGENTS: III. HETEROARYL DERIVATIVES | Bristol-Myers Squibb Company (US) | 2001-01-10 | — | — | EP | disclosed |
| US-6096745-A | EATING DISORDERS | BRISTOL-MYERS SQUIBB CO. (US) | 2000-08-01 | — | — | US | disclosed |
| WO-1999048887-A1 | IMIDAZOLONE ANORECTIC AGENTS: III. HETEROARYL DERIVATIVES | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-09-30 | — | — | WO | disclosed |