SCHEMBL6587104

SCHEMBL6587104

NC1CCN(C(C(=O)Nc2ccccc2)C2CCNCC2)CC1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR1E P28566 2/20 0.44
S1PR3 Q99500 2/20 0.44
MEN1 O00255 1/20 0.44
LMNA P02545 1/20 0.44
MAPT P10636 1/20 0.44
KMT2A Q03164 1/20 0.44
POLB P06746 1/20 0.43
JAK3 P52333 1/20 0.41
CCR2 P41597 1/20 0.41
ALDH1A1 P00352 1/20 0.41
NAMPT P43490 1/20 0.39
CACNA2D1 P54289 1/20 0.39
CACNA1B Q00975 1/20 0.39
CACNB1 Q02641 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP2D6 P10635 1/20 0.39
SMYD3 Q9H7B4 1/20 0.39
KDM4E B2RXH2 1/20 0.38
TPSAB1 Q15661 1/20 0.38
TPSD1 Q9BZJ3 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6586012 0.80 SMYD3 (0.32) SMYD3
SCHEMBL15558681 0.78 MAPT (0.48) HTR1ES1PR3MEN1LMNAMAPT
SCHEMBL6584371 0.76 CSNK1A1 (0.45) CACNA2D1CACNA1BCACNB1
SCHEMBL6584546 0.74 SLC6A2 (0.35) CACNA2D1CACNA1BCACNB1
SCHEMBL6585188 0.74 CPN1 (0.34) CCR2CACNA2D1CACNA1BCACNB1
SCHEMBL29582859 0.73 EPHX2 (0.50) HTR1ES1PR3MEN1LMNAMAPT
SCHEMBL6588940 0.73 HTR4 (0.62) CYP1A2CYP2D6
SCHEMBL6585899 0.72 SLC6A3 (0.43) CCR2
SCHEMBL6586743 0.71 CPN1 (0.32)
SCHEMBL6584313 0.70 DPP4 (0.37) CACNA2D1CACNA1BCACNB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1076055-B1 1- (1-SUBSTITUTED-4-PIPERIDINYL)METHYL]-4-PIPERIDINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES OF THESE COMPOUNDS DAINIPPON PHARMACEUTICAL CO (JP) 2004-11-24 EP disclosed
US-6294555-B1 SEROTONIN HT3 RECEPTOR ANTAGONIST FOR GASTROINTESTINAL DISORDERS DAINIPPON PHARMACEUTICAL CO., LTD. (JP) 2001-09-25 US disclosed
EP-1076055-A1 1- (1-SUBSTITUTED-4-PIPERIDINYL)METHYL]-4-PIPERIDINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES OF THESE COMPOUNDS Dainippon Pharmaceutical Co., Ltd. (JP) 2001-02-14 EP disclosed