Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBFB | Q13951 | 3/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 14/20 | 0.46 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.39 |
| ▸ | PIM1 | P11309 | 2/20 | 0.39 |
| ▸ | GSK3A | P49840 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6585381 | 0.82 | CBFB (0.67) | CBFBALOX15ALDH1A1TP53CYP3A4 | |
| SCHEMBL124235 | 0.81 | CBFB (0.68) | CBFBALOX15ALDH1A1TP53CYP3A4 | |
| SCHEMBL6805347 | 0.81 | PARP1 (0.63) | ALOX15PARP1PLA2G2APTGS2DHODH | |
| SCHEMBL6590890 | 0.78 | METAP2 (0.50) | CBFBALOX15ALDH1A1TP53CYP3A4 | |
| SCHEMBL6591503 | 0.78 | PARP1 (0.44) | ALOX15ALDH1A1TP53HPGDSMN1; SMN2 | |
| SCHEMBL7479706 | 0.78 | PARP1 (0.49) | ALOX15PARP1HPSEPLA2G2APTGS2 | |
| SCHEMBL6587744 | 0.78 | CBFB (0.44) | CBFBALOX15ALDH1A1TP53CYP3A4 | |
| SCHEMBL6591203 | 0.78 | PIM1 (0.54) | CBFBALOX15ALDH1A1TP53CYP3A4 | |
| SCHEMBL6587182 | 0.77 | MEN1 (0.52) | CBFBALOX15ALDH1A1TP53CYP3A4 | |
| SCHEMBL6592136 | 0.77 | PARP1 (0.43) | CBFBALOX15ALDH1A1TP53CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177178-B1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | ABBOTT GMBH & CO KG (DE) | 2004-12-29 | — | — | EP | disclosed |
| EP-1177178-A1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | BASF AKTIENGESELLSCHAFT (DE) | 2002-02-06 | — | — | EP | disclosed |
| WO-2001082877-A2 | USE OF PARP INHIBITORS IN COSMETIC PREPARATIONS | BASF AKTIENGESELLSCHAFT (DE) | 2001-11-08 | — | — | WO | disclosed |
| WO-2000068206-A1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | BASF AKTIENGESELLSCHAFT (DE) | 2000-11-16 | — | — | WO | disclosed |