SCHEMBL6587380

SCHEMBL6587380

CCc1cc2c(cc1OC)CC(=O)N2

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SRC P12931 2/20 0.45
EGFR P00533 1/20 0.45
ABCB1 P08183 1/20 0.44
EIF2AK2 P19525 1/20 0.42
TAAR1 Q96RJ0 2/20 0.41
AHR P35869 4/20 0.40
CMA1 P23946 2/20 0.40
PDE3B Q13370 1/20 0.39
PDE3A Q14432 1/20 0.39
CYP3A4 P08684 1/20 0.38
MAPT P10636 1/20 0.38
PLK1 P53350 1/20 0.38
TDP2 O95551 2/20 0.38
CDK4 P11802 1/20 0.37
CCND1 P24385 1/20 0.37
GSK3B P49841 1/20 0.37
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
GRIA1 P42261 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL578508 0.84 SRC (0.57) SRCEGFRABCB1EIF2AK2AHR
SCHEMBL5371439 0.79 ACHE (0.46) SRCEGFRABCB1EIF2AK2AHR
SCHEMBL31040248 0.79 AHR (0.49) SRCEGFRABCB1EIF2AK2AHR
SCHEMBL4976325 0.78 GRIA1 (0.46) EIF2AK2AHRCMA1PDE3BPDE3A
SCHEMBL5499457 0.77 AHR (0.42) EIF2AK2AHRCMA1PDE3BPDE3A
SCHEMBL5783183 0.77 S1PR1 (0.51) SRCEGFREIF2AK2AHRCMA1
SCHEMBL13619932 0.75 SRC (0.46) SRCEGFRABCB1EIF2AK2AHR
SCHEMBL31335802 0.75 AHR (0.49) SRCEGFREIF2AK2AHRCMA1
SCHEMBL23718361 0.75 TAAR1 (0.57) TAAR1CYP3A4MAPTCDK4CCND1
SCHEMBL10645877 0.75 CYP3A4 (0.62) SRCEGFRABCB1CYP3A4MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1458394-A1 USE OF OXINDOLE DERIVATIVES IN THE TREATMENT OF DEMENTIA RELATED DISEASES, ALZHEIMER S DISEASE AND CONDITIONS ASSOCIATED WITH GLYCOGEN SYNTHASE KINASE-3 AstraZeneca AB (SE) 2004-09-22 EP disclosed
WO-2003055492-A1 USE OF OXINDOLE DERIVATIVES IN THE TREATMENT OF DEMENTIA RELATED DISEASES, ALZHEIMER'S DISEASE AND CONDITIONS ASSOCIATED WITH GLYCOGEN SYNTHASE KINASE-3 ASTRAZENECA AB (SE) 2003-07-10 WO disclosed