Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | TDP2 | O95551 | 2/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.43 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.43 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL578508 | 0.86 | SRC (0.57) | CYP3A4MAPTGAASRCEGFR | |
| SCHEMBL3560449 | 0.83 | TDP2 (0.57) | CYP3A4MAPTTDP2CYP1A2CYP2C9 | |
| SCHEMBL23364490 | 0.82 | CYP3A4 (0.56) | CYP3A4MAPTGAASMN1; SMN2SRC | |
| SCHEMBL16864344 | 0.80 | CYP3A4 (0.41) | CYP3A4MAPTGAASMN1; SMN2SRC | |
| SCHEMBL6585554 | 0.79 | CYP3A4 (0.71) | CYP3A4MAPTGAASMN1; SMN2KMT2A | |
| SCHEMBL24795 | 0.79 | CYP3A4 (0.52) | CYP3A4MAPTGAASMN1; SMN2CRHBP | |
| SCHEMBL4571013 | 0.78 | CYP3A4 (1.00) | CYP3A4MAPTGAASMN1; SMN2CYP2C9 | |
| SCHEMBL22953335 | 0.78 | CYP3A4 (1.00) | CYP3A4MAPTGAASMN1; SMN2CYP2C9 | |
| SCHEMBL2138785 | 0.78 | CYP3A4 (1.00) | CYP3A4MAPTGAASMN1; SMN2CYP2C9 | |
| SCHEMBL29394312 | 0.78 | CYP3A4 (1.00) | CYP3A4MAPTGAASMN1; SMN2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2784066-B1 | Process for the synthesis of derivatives of 7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one and its use for the preparation of ivabradine | SERVIER LAB (FR) | 2015-07-01 | — | — | EP | disclosed |
| EP-2784066-B1 | Process for the synthesis of derivatives of 7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one and its use for the preparation of ivabradine | SERVIER LAB (FR) | 2015-07-01 | — | — | EP | disclosed |
| US-8927708-B2 | Process for the synthesis of 7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one compounds, and application in the synthesis of ivabradine | LES LABORATOIRES SERVIER (FR) | 2015-01-06 | — | — | US | disclosed |
| US-8927708-B2 | Process for the synthesis of 7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one compounds, and application in the synthesis of ivabradine | LES LABORATOIRES SERVIER (FR) | 2015-01-06 | — | — | US | disclosed |
| US-20140296512-A1 | PROCESS FOR THE SYNTHESIS OF 7,8-DIMETHOXY-1,3-DIHYDRO-2H-3-BENZAZEPIN-2-ONE COMPOUNDS, AND APPLICATION IN THE SYNTHESIS OF IVABRADINE | LES LABORATOIRES SERVIER (FR) | 2014-10-02 | — | — | US | disclosed |
| US-20140296512-A1 | PROCESS FOR THE SYNTHESIS OF 7,8-DIMETHOXY-1,3-DIHYDRO-2H-3-BENZAZEPIN-2-ONE COMPOUNDS, AND APPLICATION IN THE SYNTHESIS OF IVABRADINE | LES LABORATOIRES SERVIER (FR) | 2014-10-02 | — | — | US | disclosed |
| WO-2014154994-A1 | METHOD FOR THE SYNTHESIS OF DERIVATIVES OF 7,8-DIMETHOXY-1,3-DIHYDRO-2H-3-BENZAZEPIN-2-ONE AND APPLICATION TO THE SYNTHESIS OF IVABRADINE | LES LABORATOIRES SERVIER (FR) | 2014-10-02 | — | — | WO | disclosed |
| WO-2014154994-A1 | METHOD FOR THE SYNTHESIS OF DERIVATIVES OF 7,8-DIMETHOXY-1,3-DIHYDRO-2H-3-BENZAZEPIN-2-ONE AND APPLICATION TO THE SYNTHESIS OF IVABRADINE | LES LABORATOIRES SERVIER (FR) | 2014-10-02 | — | — | WO | disclosed |
| EP-2784066-A1 | Process for the synthesis of derivatives of 7,8-dimethoxy-1,3-dihydro-2h-3-benzazépin-2-one and its use for the preparation of ivabradine | Les Laboratoires Servier (FR) | 2014-10-01 | — | — | EP | disclosed |
| EP-2784066-A1 | Process for the synthesis of derivatives of 7,8-dimethoxy-1,3-dihydro-2h-3-benzazépin-2-one and its use for the preparation of ivabradine | Les Laboratoires Servier (FR) | 2014-10-01 | — | — | EP | disclosed |
| EP-0146787-B1 | INDOLE DERIVATIVES, MEDICAMENTS CONTAINING THESE COMPOUNDS, AND PROCESS FOR THEIR PREPARATION | Dr. Karl Thomae GmbH (DE) | 1988-08-17 | — | — | EP | disclosed |
| US-4737495-A | ANTIALLERGENS, ANTISCHEMIC, HYPOTENSIVE AGENTS | DR. KARL TOMAE, GMBH (DE) | 1988-04-12 | — | — | US | disclosed |
| EP-0204349-A2 | Heteroaromatic amine derivatives, medicaments containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1986-12-10 | — | — | EP | disclosed |
| US-4616011-A | BRADYCARDIAL AND ANTIISCHEMIC AGENTS; CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1986-10-07 | — | — | US | disclosed |
| US-4584293-A | LOWER HEART RATE AND OXYGEN REQUIREMENT | DR. KARL THOMAE GMBH (DE) | 1986-04-22 | — | — | US | disclosed |
| EP-0161604-A2 | Aminotetralin derivatives, medicines containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1985-11-21 | — | — | EP | disclosed |
| EP-0065229-B1 | BENZAZEPINES, PROCESS FOR THEIR PREPARATION AND THEIR APPLICATION AS PHARMACEUTICAL PREPARATIONS | Dr. Karl Thomae GmbH (DE) | 1985-08-07 | — | — | EP | disclosed |
| EP-0146787-A2 | Indole derivatives, medicaments containing these compounds, and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1985-07-03 | — | — | EP | disclosed |
| US-4490369-A | HYPOTENSIVE, BRRADYCARDIAL | DR. KARL THOMAE GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1984-12-25 | — | — | US | disclosed |
| EP-0065229-A1 | Benzazepines, process for their preparation and their application as pharmaceutical preparations | Dr. Karl Thomae GmbH (DE) | 1982-11-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140296512-A1 | PROCESS FOR THE SYNTHESIS OF 7,8-DIMETHOXY-1,3-DIHYDRO-2H-3-BENZAZEPIN-2-ONE COMPOUNDS, AND APPLICATION IN THE SYNTHESIS OF IVABRADINE | KCNB1, KCNB2, KCNMB1 | CYP3A4 138/4885MAPT 4810/4885GAA 1049/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.