Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 18/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.34 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6587507 | 1.00 | HTR3A (0.41) | HTR3ANR4A2PLA2G2A | |
| SCHEMBL6592296 | 0.86 | NR4A2 (0.44) | NR4A2 | |
| SCHEMBL7655177 | 0.83 | HTR3A (0.44) | HTR3ANR4A2 | |
| SCHEMBL6588847 | 0.81 | HTR3A (0.54) | HTR3A | |
| SCHEMBL6588840 | 0.81 | HTR3A (0.54) | HTR3A | |
| SCHEMBL7665245 | 0.79 | HTR3A (0.41) | HTR3A | |
| SCHEMBL7661258 | 0.74 | HTR3A (0.42) | HTR3A | |
| SCHEMBL14440312 | 0.70 | ICMT (0.40) | PLA2G2A | |
| SCHEMBL7667532 | 0.67 | HTR3A (0.51) | HTR3A | |
| SCHEMBL6588979 | 0.67 | HTR3A (0.51) | HTR3ANR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183252-B1 | PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-18 | — | — | EP | disclosed |
| US-6492406-B1 | PROTEIN KINASE C INHIBITORS; ANTIINFLAMMATORY AND IMMUNO-SUPPRESSIVE AGENTS | ASTRAZENECA AB (SE) | 2002-12-10 | — | — | US | disclosed |