Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6592297 | 1.00 | NR4A2 (0.44) | NR4A2KMT2AMEN1ALDH1A1GAA | |
| SCHEMBL6587507 | 0.86 | HTR3A (0.41) | NR4A2 | |
| SCHEMBL6587504 | 0.86 | HTR3A (0.41) | NR4A2 | |
| SCHEMBL14440312 | 0.81 | ICMT (0.40) | KDM4ELMNAL3MBTL1POLB | |
| SCHEMBL6588982 | 0.80 | HTR3A (0.51) | NR4A2KMT2AMEN1ALDH1A1GAA | |
| SCHEMBL6588979 | 0.80 | HTR3A (0.51) | NR4A2KMT2AMEN1ALDH1A1GAA | |
| SCHEMBL6592321 | 0.69 | HTR3A (0.48) | KMT2AMEN1ALDH1A1GAAKDM4E | |
| SCHEMBL6592314 | 0.69 | HTR3A (0.48) | KMT2AMEN1ALDH1A1GAAKDM4E | |
| SCHEMBL14440313 | 0.68 | CAMK2D (0.39) | — | |
| SCHEMBL7655177 | 0.68 | HTR3A (0.44) | NR4A2KMT2AMEN1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183252-B1 | PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-18 | — | — | EP | disclosed |
| US-6492406-B1 | PROTEIN KINASE C INHIBITORS; ANTIINFLAMMATORY AND IMMUNO-SUPPRESSIVE AGENTS | ASTRAZENECA AB (SE) | 2002-12-10 | — | — | US | disclosed |