Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6601819 | 0.71 | BACE1 (0.49) | BACE1BACE2LMNAGLATHRB | |
| SCHEMBL8172406 | 0.71 | BACE1 (0.49) | BACE1BACE2LMNAGLATHRB | |
| SCHEMBL6829481 | 0.69 | KMT2A (0.50) | BACE1BACE2LMNAGLATHRB | |
| SCHEMBL20135772 | 0.69 | TAAR1 (0.73) | TAAR1SMN1; SMN2HCAR2TSHRNPC1 | |
| SCHEMBL8175293 | 0.67 | BACE1 (0.51) | BACE1BACE2LMNAGLATHRB | |
| SCHEMBL6333918 | 0.66 | TAAR1 (0.57) | LMNACYP2C9TAAR1SMN1; SMN2TSHR | |
| SCHEMBL20146704 | 0.65 | TAAR1 (0.73) | TAAR1SMN1; SMN2TSHRNPC1 | |
| SCHEMBL8162305 | 0.65 | BACE1 (0.49) | BACE1BACE2LMNAGLATHRB | |
| SCHEMBL8169666 | 0.64 | BACE1 (0.47) | BACE1BACE2LMNAGLATHRB | |
| SCHEMBL8571535 | 0.63 | TAAR1 (0.70) | TAAR1SMN1; SMN2TSHRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066278-A4 | IMIDAZOLONE ANORECTIC AGENTS: III. HETEROARYL DERIVATIVES | BRISTOL MYERS SQUIBB CO (US) | 2004-09-01 | — | — | EP | disclosed |
| EP-1066278-A1 | IMIDAZOLONE ANORECTIC AGENTS: III. HETEROARYL DERIVATIVES | Bristol-Myers Squibb Company (US) | 2001-01-10 | — | — | EP | disclosed |
| US-6096745-A | EATING DISORDERS | BRISTOL-MYERS SQUIBB CO. (US) | 2000-08-01 | — | — | US | disclosed |
| WO-1999048887-A1 | IMIDAZOLONE ANORECTIC AGENTS: III. HETEROARYL DERIVATIVES | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-09-30 | — | — | WO | disclosed |