Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.47 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | CTSD | P07339 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8175293 | 0.71 | BACE1 (0.51) | BACE1BACE2LMNAGLATHRB | |
| SCHEMBL8958172 | 0.70 | BACE1 (0.50) | BACE1BACE2LMNAGLATHRB | |
| SCHEMBL8172406 | 0.69 | BACE1 (0.49) | BACE1BACE2LMNAGLATHRB | |
| SCHEMBL6601819 | 0.69 | BACE1 (0.49) | BACE1BACE2LMNAGLATHRB | |
| SCHEMBL8162305 | 0.69 | BACE1 (0.49) | BACE1BACE2LMNAGLATHRB | |
| SCHEMBL4239036 | 0.65 | BACE1 (1.00) | BACE1BACE2LMNAGLATHRB | |
| SCHEMBL6591928 | 0.65 | BACE1 (0.61) | BACE1BACE2LMNAGLATHRB | |
| SCHEMBL2980975 | 0.65 | BACE1 (0.61) | BACE1BACE2LMNAGLATHRB | |
| SCHEMBL6587747 | 0.64 | BACE1 (0.43) | BACE1BACE2LMNAGLATHRB | |
| SCHEMBL316482 | 0.61 | GBA1 (0.65) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6063934-A | Imidazolone anorectic agents: 1. 2-substituted-3,5-dihydro-5,5-diphenyl-4H-imidazol-4-ones | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-05-16 | — | — | US | disclosed |