SCHEMBL6587898

SCHEMBL6587898

COc1cccc(-c2ccc(C3=CCNCC3)cc2OC)c1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
QDPR P09417 2/20 0.60
CYP1A2 P05177 2/20 0.50
CYP3A4 P08684 2/20 0.50
TGFBR1 P36897 1/20 0.50
ACVR1 Q04771 1/20 0.50
KCNH2 Q12809 1/20 0.50
CYP1A1 P04798 1/20 0.50
CYP2E1 P05181 1/20 0.50
CYP2C8 P10632 1/20 0.50
CYP2D6 P10635 1/20 0.50
CYP2A6 P11509 1/20 0.50
CYP2C9 P11712 1/20 0.50
CYP4B1 P13584 1/20 0.50
CYP2B6 P20813 1/20 0.50
CYP3A5 P20815 1/20 0.50
CYP2A7 P20853 1/20 0.50
CYP3A7 P24462 1/20 0.50
CYP2F1 P24903 1/20 0.50
CYP2C18 P33260 1/20 0.50
CYP2C19 P33261 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6590672 0.90 QDPR (0.54) QDPRCYP1A2CYP3A4TGFBR1ACVR1
SCHEMBL7394377 0.88 HTR2C (0.60) QDPRCYP1A2CYP3A4HTR2CCD274
SCHEMBL6586935 0.88 QDPR (0.50) QDPRCYP1A2CYP3A4TGFBR1ACVR1
SCHEMBL6586294 0.87 QDPR (0.65) QDPRTGFBR1ACVR1KCNH2HTR2C
Hydrochloric Acid SCHEMBL4789235 0.87 HTR2C (0.61) QDPRCYP1A2CYP3A4HTR2CSIGMAR1
SCHEMBL14704745 0.83 QDPR (0.51) QDPRCYP1A2CYP3A4HTR2CCD274
SCHEMBL7305529 0.79 QDPR (0.76) QDPRTGFBR1ACVR1KCNH2HTR2C
SCHEMBL17548153 0.78 QDPR (0.70) QDPRCYP1A2CYP3A4TGFBR1ACVR1
SCHEMBL12479331 0.76 QDPR (0.72) QDPRCYP3A4TGFBR1ACVR1KCNH2
SCHEMBL14704908 0.76 CD274 (0.46) QDPRHTR2CCD274SIGMAR1HTR6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1036062-B1 HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE (MMP) INHIBITORS PFIZER LTD (GB) 2004-01-02 EP disclosed
US-6495568-B1 TREATMENT OF TISSUE ULCERATION, WOUND REPAIR AND SKIN DISEASES WARNER-LAMBERT COMPANY 2002-12-17 US disclosed
EP-1036062-A1 HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE (MMP) INHIBITORS Pfizer Limited (GB) 2000-09-20 EP disclosed
WO-1999029667-A1 HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE (MMP) INHIBITORS PFIZER LIMITED (GB) 1999-06-17 WO disclosed