Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.41 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | TTK | P33981 | 2/20 | 0.41 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | PDE1A | P54750 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6587095 | 0.86 | ROCK2 (0.49) | RAB9ANPC1NAMPTMAPTROCK2 | |
| SCHEMBL6585363 | 0.82 | NPC1 (0.59) | RAB9ANPC1NAMPTALDH1A1MEN1 | |
| SCHEMBL6587933 | 0.82 | RAB9A (0.48) | RAB9ANPC1PKMMAPK1NAMPT | |
| SCHEMBL6591224 | 0.82 | SMN1; SMN2 (0.55) | RAB9ANPC1MAPK1NAMPTALDH1A1 | |
| SCHEMBL6586593 | 0.81 | SMN1; SMN2 (0.59) | RAB9ANPC1PKMMAPK1ALDH1A1 | |
| SCHEMBL6585825 | 0.81 | BRAF (0.48) | RAB9ANPC1NAMPTALDH1A1MAPT | |
| SCHEMBL6590860 | 0.79 | RAF1 (0.48) | RAB9ANPC1MAPTROCK1 | |
| SCHEMBL6587574 | 0.78 | CNR1 (0.56) | RAB9ANPC1PKMMAPK1MEN1 | |
| SCHEMBL6588758 | 0.78 | SMN1; SMN2 (0.58) | ALDH1A1MEN1KMT2AMAPTP2RY14 | |
| SCHEMBL6590235 | 0.78 | CNR1 (0.57) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1071701-A4 | NON-ENDOGENOUS, CONSTITUTIVELY ACTIVATED HUMAN SEROTONIN RECEPTORS AND SMALL MOLECULE MODULATORS THEREOF | ARENA PHARM INC (US) | 2004-04-21 | — | — | EP | disclosed |
| EP-1071701-A1 | NON-ENDOGENOUS, CONSTITUTIVELY ACTIVATED HUMAN SEROTONIN RECEPTORS AND SMALL MOLECULE MODULATORS THEREOF | Arena Pharmaceuticals, Inc. (US) | 2001-01-31 | — | — | EP | disclosed |
| WO-1999052927-A1 | NON-ENDOGENOUS, CONSTITUTIVELY ACTIVATED HUMAN SEROTONIN RECEPTORS AND SMALL MOLECULE MODULATORS THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 1999-10-21 | — | — | WO | disclosed |