Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.55 |
| ▸ | QPCT | Q16769 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6585825 | 0.91 | BRAF (0.48) | SMN1; SMN2LMNAROCK2QPCTALDH1A1 | |
| SCHEMBL6585363 | 0.89 | NPC1 (0.59) | SMN1; SMN2ROCK2ALDH1A1KMT2AMEN1 | |
| SCHEMBL6587095 | 0.85 | ROCK2 (0.49) | SMN1; SMN2ROCK2L3MBTL1NPC1RAB9A | |
| SCHEMBL6591224 | 0.84 | SMN1; SMN2 (0.55) | SMN1; SMN2LMNAROCK2ALDH1A1KMT2A | |
| SCHEMBL6586589 | 0.82 | SMN1; SMN2 (0.56) | SMN1; SMN2LMNAROCK2QPCTALDH1A1 | |
| SCHEMBL6587407 | 0.81 | FPR2 (0.57) | SMN1; SMN2LMNAROCK2ALDH1A1KMT2A | |
| SCHEMBL6587936 | 0.81 | RAB9A (0.48) | ROCK2ALDH1A1KMT2AGAAMEN1 | |
| SCHEMBL4859619 | 0.79 | SMN1; SMN2 (0.56) | SMN1; SMN2LMNAROCK2QPCTALDH1A1 | |
| SCHEMBL6588758 | 0.79 | SMN1; SMN2 (0.58) | SMN1; SMN2LMNAROCK2ALDH1A1KMT2A | |
| SCHEMBL19337631 | 0.78 | SMN1; SMN2 (0.67) | SMN1; SMN2LMNAROCK2QPCTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1071701-A4 | NON-ENDOGENOUS, CONSTITUTIVELY ACTIVATED HUMAN SEROTONIN RECEPTORS AND SMALL MOLECULE MODULATORS THEREOF | ARENA PHARM INC (US) | 2004-04-21 | — | — | EP | disclosed |
| EP-1071701-A1 | NON-ENDOGENOUS, CONSTITUTIVELY ACTIVATED HUMAN SEROTONIN RECEPTORS AND SMALL MOLECULE MODULATORS THEREOF | Arena Pharmaceuticals, Inc. (US) | 2001-01-31 | — | — | EP | disclosed |
| WO-1999052927-A1 | NON-ENDOGENOUS, CONSTITUTIVELY ACTIVATED HUMAN SEROTONIN RECEPTORS AND SMALL MOLECULE MODULATORS THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 1999-10-21 | — | — | WO | disclosed |