Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 3/20 | 0.44 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PRKCA | P17252 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | GSK3A | P49840 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | RGS12 | O14924 | 1/20 | 0.35 |
| ▸ | GMNN | O75496 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6588432 | 0.95 | GSK3B (0.42) | CHEK1CAMK2DPIM1GSK3BKDM4E | |
| Trifluoroacetic Acid SCHEMBL6588835 | 0.93 | CHEK1 (0.39) | CHEK1CAMK2DPIM1GSK3BKDM4E | |
| SCHEMBL6588770 | 0.90 | KDM4E (0.41) | CHEK1GSK3BKDM4EPRKCAKMT2A | |
| Trifluoroacetic Acid SCHEMBL6590532 | 0.89 | CDK2 (0.38) | CHEK1CAMK2DPIM1GSK3BKDM4E | |
| SCHEMBL6588981 | 0.89 | CAMK2D (0.42) | CAMK2DPIM1GSK3BKDM4EGSK3A | |
| SCHEMBL27581663 | 0.89 | GSK3B (0.38) | CHEK1GSK3BKDM4EPRKCAKMT2A | |
| Hydrochloric Acid SCHEMBL6588778 | 0.88 | CAMK2D (0.42) | CAMK2DPIM1GSK3BKDM4EGSK3A | |
| SCHEMBL6588767 | 0.87 | GSK3B (0.35) | CHEK1GSK3BKDM4EPRKCAKMT2A | |
| SCHEMBL6586537 | 0.86 | PIM1 (0.40) | CAMK2DPIM1GSK3BKDM4ECDK2 | |
| SCHEMBL6589065 | 0.85 | CAMK2D (0.40) | CAMK2DPIM1GSK3BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183252-B1 | PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-18 | — | — | EP | disclosed |
| US-6492406-B1 | PROTEIN KINASE C INHIBITORS; ANTIINFLAMMATORY AND IMMUNO-SUPPRESSIVE AGENTS | ASTRAZENECA AB (SE) | 2002-12-10 | — | — | US | disclosed |