SCHEMBL6589293

SCHEMBL6589293

CS(=O)(=O)Oc1ccc(C(=O)O)cc1Cl

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.52
TTR P02766 2/20 0.49
CA12 O43570 1/20 0.47
CA1 P00915 1/20 0.47
CA2 P00918 1/20 0.47
CA4 P22748 1/20 0.47
CA6 P23280 1/20 0.47
CA7 P43166 1/20 0.47
TPMT P51580 1/20 0.47
CA9 Q16790 1/20 0.47
CA14 Q9ULX7 1/20 0.47
MRGPRX4 Q96LA9 5/20 0.47
PKM P14618 1/20 0.46
RAB9A P51151 4/20 0.45
GAA P10253 2/20 0.45
KDM4E B2RXH2 1/20 0.45
ALDH1A1 P00352 1/20 0.45
SMN1; SMN2 Q16637 3/20 0.44
NPC1 O15118 2/20 0.44
NFKB1 P19838 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL324485 0.87 ESRRA (0.47) MRGPRX4RAB9AGAAALDH1A1SMN1; SMN2
SCHEMBL7364035 0.84 TSHR (0.49) TSHRTTRCA12CA1CA2
SCHEMBL323143 0.81 GSK3B (0.45) KMT2AMEN1
SCHEMBL14164863 0.81 CA12 (0.73) TSHRTTRCA12CA1CA2
SCHEMBL7323564 0.81 F2 (0.46)
SCHEMBL4950565 0.81 TSHR (0.49) TSHRTTRCA12CA1CA2
SCHEMBL12388052 0.80 ALDH1A1 (0.51) CA12CA1CA2CA7CA9
SCHEMBL6565752 0.80 CA12 (0.71) TSHRTTRCA12CA1CA2
SCHEMBL308170 0.79 TPMT (0.69) TSHRTTRCA12CA1CA2
SCHEMBL29524334 0.79 TPMT (0.69) TSHRTTRCA12CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1144409-B1 PHENYL UREA AND PHENYL THIOUREA DERIVATIVES SMITHKLINE BEECHAM PLC (GB) 2004-11-17 EP disclosed
EP-1150977-B1 PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 2004-08-25 EP disclosed
US-6699879-B1 OBESITY, DIABETES, SLEEP DISORDERS SMITHKLINE BEECHAM P.L.C. (GB) 2004-03-02 US disclosed
US-6596730-B1 Phenyl urea and phenyl thiourea derivatives SMITHKLINE BEECHAM P.L.C. (GB) 2003-07-22 US disclosed
EP-1150977-A1 PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 2001-11-07 EP disclosed
WO-2000047577-A1 PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 2000-08-17 WO disclosed