Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | MRGPRX4 | Q96LA9 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | TTR | P02766 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6589293 | 0.84 | TSHR (0.52) | TSHRSMN1; SMN2RAB9ANPC1NFKB1 | |
| SCHEMBL566498 | 0.79 | POLB (0.70) | TSHRSMN1; SMN2RAB9ANPC1NFKB1 | |
| SCHEMBL4950565 | 0.78 | TSHR (0.49) | TSHRSMN1; SMN2RAB9ANPC1MRGPRX4 | |
| SCHEMBL29524334 | 0.76 | TPMT (0.69) | TSHRRAB9ANPC1MRGPRX4KMT2A | |
| SCHEMBL308170 | 0.76 | TPMT (0.69) | TSHRRAB9ANPC1MRGPRX4KMT2A | |
| SCHEMBL177169 | 0.76 | THRA (0.56) | SMN1; SMN2RAB9ANPC1NFKB1NFKB2 | |
| SCHEMBL566426 | 0.75 | THRA (0.62) | TSHRSMN1; SMN2RAB9ANPC1NFKB1 | |
| SCHEMBL566466 | 0.75 | THRA (0.66) | TSHRSMN1; SMN2RAB9ANPC1NFKB1 | |
| Hydrochloric Acid SCHEMBL306990 | 0.75 | CA12 (0.67) | TSHRRAB9ANPC1MRGPRX4KMT2A | |
| SCHEMBL337560 | 0.75 | MRGPRX4 (0.58) | TSHRSMN1; SMN2RAB9ANPC1NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144409-A2 | PHENYL UREA AND PHENYL THIOUREA DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000047580-A2 | PHENYL UREA AND PHENYL THIOUREA DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 2000-08-17 | — | — | WO | disclosed |